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Id Subject Object Predicate Lexical cue
T1 0-89 Sentence denotes Human alveolar macrophages are markedly deficient in REF-1 and AP-1 DNA binding activity.
T2 90-291 Sentence denotes Although many functions of human alveolar macrophages are altered compared with their precursor cell, the blood monocyte (monocyte), the reason(s) for these functional changes have not been determined.
T3 292-397 Sentence denotes We recently reported that human alveolar macrophages do not express AP-1 DNA binding activity (Monick, M.
T4 398-412 Sentence denotes M., Carter, A.
T5 413-443 Sentence denotes B., Gudmundsson, G., Geist, L.
T6 444-467 Sentence denotes J., and Hunninghake, G.
T7 468-481 Sentence denotes W. (1998) Am.
T8 482-484 Sentence denotes J.
T9 485-493 Sentence denotes Physiol.
T10 494-510 Sentence denotes 275, L389-L397).
T11 511-709 Sentence denotes To determine why alveolar macrophages do not express AP-1 DNA binding activity, we first showed that there was not a decrease in expression of the FOS and JUN proteins that make up the AP-1 complex.
T12 710-937 Sentence denotes There was, however, a significant difference in the amounts of the nuclear protein, REF-1 (which regulates AP-1 DNA binding by altering the redox status of FOS and JUN proteins), in alveolar macrophages compared with monocytes.
T13 938-1054 Sentence denotes In addition, in vitro differentiation of monocytes to a macrophage-like cell resulted in decreased amounts of REF-1.
T14 1055-1197 Sentence denotes Finally, addition of REF-1 from activated monocytes to alveolar macrophage nuclear proteins resulted in a marked increase in AP-1 DNA binding.
T15 1198-1357 Sentence denotes These studies strongly suggest that the process of differentiation of monocytes into alveolar macrophages is associated with a loss of REF-1 and AP-1 activity.
T16 1358-1490 Sentence denotes This observation may explain, in part, some of the functional differences observed for alveolar macrophages compared with monocytes.