| Id |
Subject |
Object |
Predicate |
Lexical cue |
| TextSentencer_T1 |
0-95 |
Sentence |
denotes |
Structural features in heparin that interact with VEGF165 and modulate its biological activity. |
| T1 |
0-95 |
Sentence |
denotes |
Structural features in heparin that interact with VEGF165 and modulate its biological activity. |
| T1 |
0-95 |
Sentence |
denotes |
Structural features in heparin that interact with VEGF165 and modulate its biological activity. |
| TextSentencer_T2 |
96-258 |
Sentence |
denotes |
The 165 amino acid form of vascular endothelial growth factor (VEGF165) is a heparin-binding growth factor with mitogenic activity for vascular endothelial cells. |
| T2 |
96-258 |
Sentence |
denotes |
The 165 amino acid form of vascular endothelial growth factor (VEGF165) is a heparin-binding growth factor with mitogenic activity for vascular endothelial cells. |
| T2 |
96-258 |
Sentence |
denotes |
The 165 amino acid form of vascular endothelial growth factor (VEGF165) is a heparin-binding growth factor with mitogenic activity for vascular endothelial cells. |
| TextSentencer_T3 |
259-466 |
Sentence |
denotes |
We examined activities of various heparin derivatives toward their interactions with VEGF165 using an enzyme-linked immunosorbent assay and elucidated the structural features in heparin for the interactions. |
| T3 |
259-466 |
Sentence |
denotes |
We examined activities of various heparin derivatives toward their interactions with VEGF165 using an enzyme-linked immunosorbent assay and elucidated the structural features in heparin for the interactions. |
| T3 |
259-466 |
Sentence |
denotes |
We examined activities of various heparin derivatives toward their interactions with VEGF165 using an enzyme-linked immunosorbent assay and elucidated the structural features in heparin for the interactions. |
| TextSentencer_T4 |
467-610 |
Sentence |
denotes |
Native heparin interacted with VEGF165, whereas N-desulfated, N-acetylated (N-DS, N-Ac-) heparin, and 6-O-desulfated (6-O-DS-) heparin did not. |
| T4 |
467-610 |
Sentence |
denotes |
Native heparin interacted with VEGF165, whereas N-desulfated, N-acetylated (N-DS, N-Ac-) heparin, and 6-O-desulfated (6-O-DS-) heparin did not. |
| T4 |
467-610 |
Sentence |
denotes |
Native heparin interacted with VEGF165, whereas N-desulfated, N-acetylated (N-DS, N-Ac-) heparin, and 6-O-desulfated (6-O-DS-) heparin did not. |
| TextSentencer_T5 |
611-702 |
Sentence |
denotes |
The 2-O-desulfated (2-O-DS-) heparin retained the ability for the interaction with VEGF165. |
| T5 |
611-702 |
Sentence |
denotes |
The 2-O-desulfated (2-O-DS-) heparin retained the ability for the interaction with VEGF165. |
| T5 |
611-702 |
Sentence |
denotes |
The 2-O-desulfated (2-O-DS-) heparin retained the ability for the interaction with VEGF165. |
| TextSentencer_T6 |
703-795 |
Sentence |
denotes |
In contrast, the 2-O-DS-heparin exhibited no ability for the interaction with FGF-2 and HGF. |
| T6 |
703-795 |
Sentence |
denotes |
In contrast, the 2-O-DS-heparin exhibited no ability for the interaction with FGF-2 and HGF. |
| T6 |
703-795 |
Sentence |
denotes |
In contrast, the 2-O-DS-heparin exhibited no ability for the interaction with FGF-2 and HGF. |
| TextSentencer_T7 |
796-973 |
Sentence |
denotes |
Thus, structural requirements in heparin for the specific interaction with VEGF165 are distinct from those with FGF-2 and HGF which require a high content of 2-O-sulfate groups. |
| T7 |
796-973 |
Sentence |
denotes |
Thus, structural requirements in heparin for the specific interaction with VEGF165 are distinct from those with FGF-2 and HGF which require a high content of 2-O-sulfate groups. |
| T7 |
796-973 |
Sentence |
denotes |
Thus, structural requirements in heparin for the specific interaction with VEGF165 are distinct from those with FGF-2 and HGF which require a high content of 2-O-sulfate groups. |
| TextSentencer_T8 |
974-1300 |
Sentence |
denotes |
In a cell proliferation assay, native heparin and 2-O-DS-heparin exhibited inhibitory abilities for VEGF165-induced proliferation of human umbilical vein endothelial cells (HUVECs) with their high concentrations (more than 64 microg/ml), while only native heparin could enhance the proliferation of the chlorate-treated cells. |
| T8 |
974-1300 |
Sentence |
denotes |
In a cell proliferation assay, native heparin and 2-O-DS-heparin exhibited inhibitory abilities for VEGF165-induced proliferation of human umbilical vein endothelial cells (HUVECs) with their high concentrations (more than 64 microg/ml), while only native heparin could enhance the proliferation of the chlorate-treated cells. |
| T8 |
974-1300 |
Sentence |
denotes |
In a cell proliferation assay, native heparin and 2-O-DS-heparin exhibited inhibitory abilities for VEGF165-induced proliferation of human umbilical vein endothelial cells (HUVECs) with their high concentrations (more than 64 microg/ml), while only native heparin could enhance the proliferation of the chlorate-treated cells. |
| TextSentencer_T9 |
1301-1504 |
Sentence |
denotes |
These results suggested that a high content of 2-O-sulfate groups is not required for the specific interaction with VEGF165alone, although it is essential for the mitogenic activity of the growth factor. |
| T9 |
1301-1504 |
Sentence |
denotes |
These results suggested that a high content of 2-O-sulfate groups is not required for the specific interaction with VEGF165alone, although it is essential for the mitogenic activity of the growth factor. |
| T9 |
1301-1504 |
Sentence |
denotes |
These results suggested that a high content of 2-O-sulfate groups is not required for the specific interaction with VEGF165alone, although it is essential for the mitogenic activity of the growth factor. |