> top > projects > sentences > docs > PubMed:10330423 > annotations
sentences Home  

PubMed:10330423 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-116 Sentence denotes Estrogen's bone-protective effects may involve differential IL-1 receptor regulation in human osteoclast-like cells.
T1 0-116 Sentence denotes Estrogen's bone-protective effects may involve differential IL-1 receptor regulation in human osteoclast-like cells.
TextSentencer_T2 117-287 Sentence denotes Declining estrogen levels during the first postmenopausal decade lead to rapid bone loss and increased fracture risk that can be reversed by estrogen replacement therapy.
T2 117-287 Sentence denotes Declining estrogen levels during the first postmenopausal decade lead to rapid bone loss and increased fracture risk that can be reversed by estrogen replacement therapy.
TextSentencer_T3 288-465 Sentence denotes The bone-protective effects of estrogen may involve suppression of inflammatory cytokines that promote osteoclastogenesis and bone resorption, such as IL-1, TNF-alpha, and IL-6.
T3 288-465 Sentence denotes The bone-protective effects of estrogen may involve suppression of inflammatory cytokines that promote osteoclastogenesis and bone resorption, such as IL-1, TNF-alpha, and IL-6.
TextSentencer_T4 466-575 Sentence denotes We investigated whether estrogen modulates IL-1 actions on human osteoclasts (OCs) and other bone cell types.
T4 466-575 Sentence denotes We investigated whether estrogen modulates IL-1 actions on human osteoclasts (OCs) and other bone cell types.
TextSentencer_T5 576-763 Sentence denotes Isolated human OCs and primary bone marrow-derived OC-like cells expressed both the signaling (IL-1RI) and decoy (IL-1RII) IL-1 receptors, whereas only IL-1RI was detected in osteoblasts.
T5 576-763 Sentence denotes Isolated human OCs and primary bone marrow-derived OC-like cells expressed both the signaling (IL-1RI) and decoy (IL-1RII) IL-1 receptors, whereas only IL-1RI was detected in osteoblasts.
TextSentencer_T6 764-1067 Sentence denotes IL-1RII/IL-1RI mRNA ratios and release of soluble IL-1RII (sIL-1RII) were lower in OC-like cells derived from women in the late postmenopausal period compared with younger women, but were unrelated to male donor age, suggesting that estrogen might play a role in regulating IL-1 receptor levels in vivo.
T6 764-1067 Sentence denotes IL-1RII/IL-1RI mRNA ratios and release of soluble IL-1RII (sIL-1RII) were lower in OC-like cells derived from women in the late postmenopausal period compared with younger women, but were unrelated to male donor age, suggesting that estrogen might play a role in regulating IL-1 receptor levels in vivo.
TextSentencer_T7 1068-1193 Sentence denotes Estrogen directly reduced in vitro OC-like cell IL-1RI mRNA levels while increasing IL-1RII mRNA levels and sIL-1RII release.
T7 1068-1193 Sentence denotes Estrogen directly reduced in vitro OC-like cell IL-1RI mRNA levels while increasing IL-1RII mRNA levels and sIL-1RII release.
TextSentencer_T8 1194-1339 Sentence denotes These estrogenic events were associated with inhibited IL-1-mediated cytokine (IL-8) mRNA induction and cell survival, i.e., increased apoptosis.
T8 1194-1339 Sentence denotes These estrogenic events were associated with inhibited IL-1-mediated cytokine (IL-8) mRNA induction and cell survival, i.e., increased apoptosis.
TextSentencer_T9 1340-1470 Sentence denotes In contrast, estrogen did not alter IL-1R levels or IL-1 responsiveness in primary human osteoblasts or bone marrow stromal cells.
T9 1340-1470 Sentence denotes In contrast, estrogen did not alter IL-1R levels or IL-1 responsiveness in primary human osteoblasts or bone marrow stromal cells.
TextSentencer_T10 1471-1701 Sentence denotes We conclude that one novel mechanism by which estrogen exerts bone-protective effects may include a selective modulation of IL-1R isoform levels in OC or OC-like cells, thereby reducing their IL-1 responsiveness and cell survival.
T10 1471-1701 Sentence denotes We conclude that one novel mechanism by which estrogen exerts bone-protective effects may include a selective modulation of IL-1R isoform levels in OC or OC-like cells, thereby reducing their IL-1 responsiveness and cell survival.
TextSentencer_T11 1702-1865 Sentence denotes Conversely, this restraint on IL-1 actions may be lost as estrogen levels decline in aging women, contributing to an enhanced OC-mediated postmenopausal bone loss.
T11 1702-1865 Sentence denotes Conversely, this restraint on IL-1 actions may be lost as estrogen levels decline in aging women, contributing to an enhanced OC-mediated postmenopausal bone loss.