| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-114 |
Sentence |
denotes |
A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis. |
| T2 |
115-213 |
Sentence |
denotes |
TR6 (decoy receptor 3 (DcR3)) is a new member of the tumor necrosis factor receptor (TNFR) family. |
| T3 |
214-284 |
Sentence |
denotes |
TR6 mRNA is expressed in lung tissues and colon adenocarcinoma, SW480. |
| T4 |
285-448 |
Sentence |
denotes |
In addition, the expression of TR6 mRNA was shown in the endothelial cell line and induced by phorbol 12-myristate 13-acetate/ionomycin in Jurkat T leukemia cells. |
| T5 |
449-565 |
Sentence |
denotes |
The open reading frame of TR6 encodes 300 amino acids with a 29-residue signal sequence but no transmembrane region. |
| T6 |
566-680 |
Sentence |
denotes |
Using histidine-tagged recombinant TR6, we screened soluble forms of TNF-ligand proteins with immunoprecipitation. |
| T7 |
681-825 |
Sentence |
denotes |
Here, we demonstrate that TR6 specifically binds two cellular ligands, LIGHT (herpes virus entry mediator (HVEM)-L) and Fas ligand (FasL/CD95L). |
| T8 |
826-926 |
Sentence |
denotes |
These bindings were confirmed with HEK 293 EBNA cells transfected with LIGHT cDNA by flow cytometry. |
| T9 |
927-982 |
Sentence |
denotes |
TR6 inhibited LIGHT-induced cytotoxicity in HT29 cells. |
| T10 |
983-1152 |
Sentence |
denotes |
It has been shown that LIGHT triggers apoptosis of various tumor cells including HT29 cells that express both lymphotoxin beta receptor (LTbetaR) and HVEM/TR2 receptors. |
| T11 |
1153-1293 |
Sentence |
denotes |
Our data suggest that TR6 inhibits the interactions of LIGHT with HVEM/TR2 and LTbetaR, thereby suppressing LIGHT- mediated HT29 cell death. |
| T12 |
1294-1386 |
Sentence |
denotes |
Thus, TR6 may play a regulatory role for suppressing in FasL- and LIGHT-mediated cell death. |
