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PubMed:10224130 JSONTXT 21 Projects

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Id Subject Object Predicate Lexical cue
T1 0-140 Sentence denotes Regulation of NF-kappaB RelA phosphorylation and transcriptional activity by p21(ras) and protein kinase Czeta in primary endothelial cells.
T2 141-277 Sentence denotes The activity of the transcription factor NF-kappaB is thought to be regulated mainly through cytoplasmic retention by IkappaB molecules.
T3 278-386 Sentence denotes Here we present evidence of a second mechanism of regulation acting on NF-kappaB after release from IkappaB.
T4 387-567 Sentence denotes In endothelial cells this mechanism involves phosphorylation of the RelA subunit of NF-kappaB through a pathway involving activation of protein kinase Czeta (PKCzeta) and p21(ras).
T5 568-730 Sentence denotes We show that transcriptional activity of RelA is dependent on phosphorylation of the N-terminal Rel homology domain but not the C-terminal transactivation domain.
T6 731-899 Sentence denotes Inhibition of phosphorylation by dominant negative mutants of PKCzeta or p21(ras) results in loss of RelA transcriptional activity without interfering with DNA binding.
T7 900-1049 Sentence denotes Raf/MEK, small GTPases, phosphatidylinositol 3-kinase, and stress-activated protein kinase pathways are not involved in this mechanism of regulation.