| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-103 |
Sentence |
denotes |
Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure. |
| T2 |
104-170 |
Sentence |
denotes |
Mouse KCNK6 is a new subunit belonging to the TWIK channel family. |
| T3 |
171-295 |
Sentence |
denotes |
This 335-amino acid polypeptide has four transmembrane segments, two pore-forming domains, and a Ca2+-binding EF-hand motif. |
| T4 |
296-386 |
Sentence |
denotes |
Expression of KCNK6 transcripts is principally observed in eyes, lung, stomach and embryo. |
| T5 |
387-483 |
Sentence |
denotes |
In the eyes, immunohistochemistry reveals protein expression only in some of the retina neurons. |
| T6 |
484-690 |
Sentence |
denotes |
Although KCNK6 is able to dimerize as other functional two-P domain K+ channels when it is expressed in COS-7 cells, it remains in the endoplasmic reticulum and is unable to generate ionic channel activity. |
| T7 |
691-921 |
Sentence |
denotes |
Deletions, mutations, and chimera constructions suggest that KCNK6 is not an intracellular channel but rather a subunit that needs to associate with a partner, which remains to be discovered, in order to reach the plasma membrane. |
| T8 |
922-978 |
Sentence |
denotes |
A closely related human KCNK7-A subunit has been cloned. |
| T9 |
979-1128 |
Sentence |
denotes |
KCNK7 displays an intriguing GLE sequence in its filter region instead of the G(Y/F/L)G sequence, which is considered to be the K+ channel signature. |
| T10 |
1129-1218 |
Sentence |
denotes |
This subunit is alternatively spliced and gives rise to the shorter forms KCNK7-B and -C. |
| T11 |
1219-1288 |
Sentence |
denotes |
None of the KCNK7 structures can generate channel activity by itself. |
| T12 |
1289-1407 |
Sentence |
denotes |
The KCNK7 gene is situated on chromosome 11, in the q13 region, where several candidate diseases have been identified. |
