| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-119 |
Sentence |
denotes |
Inhibition of T cell signaling by mitogen-activated protein kinase-targeted hematopoietic tyrosine phosphatase (HePTP). |
| T2 |
120-376 |
Sentence |
denotes |
Activation of T lymphocytes to produce cytokines is regulated by the counterbalance of protein-tyrosine kinases and protein-tyrosine phosphatases, many of which have a high degree of substrate specificity because of physical association with their targets. |
| T3 |
377-632 |
Sentence |
denotes |
Overexpression of hematopoietic protein-tyrosine phosphatase (HePTP) results in suppression of T lymphocyte activation as measured by T cell antigen receptor-induced activation of transcription factors binding to the 5' promoter of the interleukin-2 gene. |
| T4 |
633-920 |
Sentence |
denotes |
Efforts to pinpoint the exact site of action and specificity of HePTP in the signaling cascade revealed that HePTP acts directly on the mitogen-activated protein (MAP) kinases Erk1 and 2 and consequently reduces the magnitude and duration of their catalytic activation in intact T cells. |
| T5 |
921-1023 |
Sentence |
denotes |
In contrast, HePTP had no effects on N-terminal c-Jun kinase or on events upstream of the MAP kinases. |
| T6 |
1024-1194 |
Sentence |
denotes |
The specificity of HePTP correlated with its physical association through its noncatalytic N terminus with Erk and another MAP kinase, p38, but not Jnk or other proteins. |
| T7 |
1195-1459 |
Sentence |
denotes |
We propose that HePTP plays a negative role in antigen receptor signaling by specifically regulating MAP kinases in the cytosol and at early time points of T cell activation before the activation-induced expression of nuclear dual-specific MAP kinase phosphatases. |
