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PubMed:10072053 JSONTXT 8 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-115 Sentence denotes Kearns-Sayre syndrome: unusual pattern of expression of subunits of the respiratory chain in the cerebellar system.
T1 0-115 Sentence denotes Kearns-Sayre syndrome: unusual pattern of expression of subunits of the respiratory chain in the cerebellar system.
TextSentencer_T2 116-286 Sentence denotes Kearns-Sayre syndrome (KSS) is a sporadic multisystem disorder of oxidative phosphorylation associated with clonally expanded rearrangements of mitochondrial DNA (mtDNA).
T2 116-286 Sentence denotes Kearns-Sayre syndrome (KSS) is a sporadic multisystem disorder of oxidative phosphorylation associated with clonally expanded rearrangements of mitochondrial DNA (mtDNA).
TextSentencer_T3 287-424 Sentence denotes Mitochondrial dysfunction in the central nervous system of patients with KSS accounts for the neurological manifestations of the disease.
T3 287-424 Sentence denotes Mitochondrial dysfunction in the central nervous system of patients with KSS accounts for the neurological manifestations of the disease.
TextSentencer_T4 425-759 Sentence denotes To gain further insight into the pathogenesis of neuronal dysfunction in KSS, we used antibodies against mtDNA-encoded and nuclear DNA-encoded subunits of the mitochondrial respiratory chain to study the expression of these proteins in the cerebellar cortex, dentate nucleus, and inferior olivary nucleus from 2 autoptic cases of KSS.
T4 425-759 Sentence denotes To gain further insight into the pathogenesis of neuronal dysfunction in KSS, we used antibodies against mtDNA-encoded and nuclear DNA-encoded subunits of the mitochondrial respiratory chain to study the expression of these proteins in the cerebellar cortex, dentate nucleus, and inferior olivary nucleus from 2 autoptic cases of KSS.
TextSentencer_T5 760-890 Sentence denotes Neuropathological examination showed a moderate loss of Purkinje cells and spongiform degeneration of the cerebellar white matter.
T5 760-890 Sentence denotes Neuropathological examination showed a moderate loss of Purkinje cells and spongiform degeneration of the cerebellar white matter.
TextSentencer_T6 891-1019 Sentence denotes By using immunohistochemistry, we found a decreased expression of mtDNA-encoded proteins only in neurons of the dentate nucleus.
T6 891-1019 Sentence denotes By using immunohistochemistry, we found a decreased expression of mtDNA-encoded proteins only in neurons of the dentate nucleus.
TextSentencer_T7 1020-1266 Sentence denotes We suggest that mitochondrial abnormalities in the dentate nucleus in conjunction with loss of Purkinje cells and spongiform degeneration of the cerebellar white matter may be important factors in the genesis of the cerebellar dysfunction in KSS.
T7 1020-1266 Sentence denotes We suggest that mitochondrial abnormalities in the dentate nucleus in conjunction with loss of Purkinje cells and spongiform degeneration of the cerebellar white matter may be important factors in the genesis of the cerebellar dysfunction in KSS.