| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-71 |
Sentence |
denotes |
Human geranylgeranyl diphosphate synthase. cDNA cloning and expression. |
| T2 |
72-309 |
Sentence |
denotes |
Geranylgeranyl diphosphate (GGPP) synthase (GGPPSase) catalyzes the synthesis of GGPP, which is an important molecule responsible for the C20-prenylated protein biosynthesis and for the regulation of a nuclear hormone receptor (LXR.RXR). |
| T3 |
310-472 |
Sentence |
denotes |
The human GGPPSase cDNA encodes a protein of 300 amino acids which shows 16% sequence identity with the known human farnesyl diphosphate (FPP) synthase (FPPSase). |
| T4 |
473-600 |
Sentence |
denotes |
The GGPPSase expressed in Escherichia coli catalyzes the GGPP formation (240 nmol/min/mg) from FPP and isopentenyl diphosphate. |
| T5 |
601-825 |
Sentence |
denotes |
The human GGPPSase behaves as an oligomeric molecule with 280 kDa on a gel filtration column and cross-reacts with an antibody directed against bovine brain GGPPSase, which differs immunochemically from bovine brain FPPSase. |
| T6 |
826-897 |
Sentence |
denotes |
Northern blot analysis indicates the presence of two forms of the mRNA. |
