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PubMed:10026206 JSONTXT 22 Projects

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Id Subject Object Predicate Lexical cue
T1 0-95 Sentence denotes CD40 signaling of monocyte inflammatory cytokine synthesis through an ERK1/2-dependent pathway.
T2 96-162 Sentence denotes A target of interleukin (il)-4 and il-10 anti-inflammatory action.
T3 163-418 Sentence denotes Ligation of CD40 on monocytes through its interaction with CD40 ligand (CD154) present on activated T helper cells, results in activation of monocyte inflammatory cytokine synthesis and rescue of monocytes from apoptosis induced through serum deprivation.
T4 419-551 Sentence denotes Both of these consequences of CD40 stimulation have been shown to be dependent on the induction of protein tyrosine kinase activity.
T5 552-784 Sentence denotes CD40-mediated activation of protein tyrosine kinase activity and subsequent inflammatory cytokine production are abrogated by treatment of monocytes with the T helper type 2 cytokines interleukin 4 (IL-4) and interleukin 10 (IL-10).
T6 785-1192 Sentence denotes In the current study we demonstrate that stimulation of monocytes through CD40 resulted in the phosphorylation and activation of the extracellular signal-regulated kinases 1 and 2 (ERK1/2) mitogen-activated protein kinases, whereas phosphorylation of mitogen-activated protein kinases family members p38 and c-Jun N-terminal kinase was not observed in response to this stimuli over the time course examined.
T7 1193-1370 Sentence denotes PD98059, an inhibitor of the upstream activator of ERK1/2, the MAP/ERK kinase MEK1/2, suppressed IL-1beta and tumor necrosis factor-alpha production in a dose-dependent fashion.
T8 1371-1561 Sentence denotes Pretreatment of monocytes with IL-4 and IL-10 inhibited CD40-mediated activation of ERK1/2 kinase activity when used individually, and are enhanced in effectiveness when used in combination.
T9 1562-1788 Sentence denotes Together, the data demonstrate that CD40-mediated induction of IL-1beta and tumor necrosis factor-alpha synthesis is dependent on a MEK/ERK pathway which is obstructed by signals generated through the action of IL-4 and IL-10.