| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-102 |
Sentence |
denotes |
Cell adhesion regulates the interaction between the docking protein p130(Cas) and the 14-3-3 proteins. |
| T2 |
103-254 |
Sentence |
denotes |
Integrin ligand binding induces a signaling complex formation via the direct association of the docking protein p130(Cas) (Cas) with diverse molecules. |
| T3 |
255-347 |
Sentence |
denotes |
We report here that the 14-3-3zeta protein interacts with Cas in the yeast two-hybrid assay. |
| T4 |
348-586 |
Sentence |
denotes |
We also found that the two proteins associate in mammalian cells and that this interaction takes place in a phosphoserine-dependent manner, because treatment of Cas with a serine phosphatase greatly reduced its ability to bind 14-3-3zeta. |
| T5 |
587-692 |
Sentence |
denotes |
Furthermore, the Cas-14-3-3zeta interaction was found to be regulated by integrin-mediated cell adhesion. |
| T6 |
693-887 |
Sentence |
denotes |
Thus, when cells are detached from the extracellular matrix, the binding of Cas to 14-3-3zeta is greatly diminished, whereas replating the cells onto fibronectin rapidly induces the association. |
| T7 |
888-1140 |
Sentence |
denotes |
Consistent with these results, we found that the subcellular localization of Cas and 14-3-3 is also regulated by integrin ligand binding and that the two proteins display a significant co-localization during cell attachment to the extracellular matrix. |
| T8 |
1141-1410 |
Sentence |
denotes |
In conclusion, our results demonstrate that 14-3-3 proteins participate in integrin-activated signaling pathways through their interaction with Cas, which, in turn, may contribute to important biological responses regulated by cell adhesion to the extracellular matrix. |
