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PubMed:10026162 JSONTXT 23 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-119 Sentence denotes A novel ubiquitously expressed alpha-latrotoxin receptor is a member of the CIRL family of G-protein-coupled receptors.
T2 120-327 Sentence denotes Poisoning with alpha-latrotoxin, a neurotoxic protein from black widow spider venom, results in a robust increase of spontaneous synaptic transmission and subsequent degeneration of affected nerve terminals.
T3 328-448 Sentence denotes The neurotoxic action of alpha-latrotoxin involves extracellular binding to its high affinity receptors as a first step.
T4 449-561 Sentence denotes One of these proteins, CIRL, is a neuronal G-protein-coupled receptor implicated in the regulation of secretion.
T5 562-682 Sentence denotes We now demonstrate that CIRL has two close homologs with a similar domain structure and high degree of overall identity.
T6 683-942 Sentence denotes These novel receptors, which we propose to name CIRL-2 and CIRL-3, together with CIRL (CIRL-1) belong to a recently identified subfamily of large orphan receptors with structural features typical of both G-protein-coupled receptors and cell adhesion proteins.
T7 943-1178 Sentence denotes Northern blotting experiments indicate that CIRL-2 is expressed ubiquitously with highest concentrations found in placenta, kidney, spleen, ovary, heart, and lung, whereas CIRL-3 is expressed predominantly in brain similarly to CIRL-1.
T8 1179-1312 Sentence denotes It appears that CIRL-2 can also bind alpha-latrotoxin, although its affinity to the toxin is about 14 times less than that of CIRL-1.
T9 1313-1463 Sentence denotes When overexpressed in chromaffin cells, CIRL-2 increases their sensitivity to alpha-latrotoxin stimulation but also inhibits Ca2+-regulated secretion.
T10 1464-1534 Sentence denotes Thus, CIRL-2 is a functionally competent receptor of alpha-latrotoxin.
T11 1535-1802 Sentence denotes Our findings suggest that although the nervous system is the primary target of low doses of alpha-latrotoxin, cells of other tissues are also susceptible to the toxic effects of alpha-latrotoxin because of the presence of CIRL-2, a low affinity receptor of the toxin.