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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-111 Sentence denotes Cell surface sialic acid and the regulation of immune cell interactions: the neuraminidase effect reconsidered.
T1 0-111 Sentence denotes Cell surface sialic acid and the regulation of immune cell interactions: the neuraminidase effect reconsidered.
T1 0-111 Sentence denotes Cell surface sialic acid and the regulation of immune cell interactions: the neuraminidase effect reconsidered.
TextSentencer_T2 112-334 Sentence denotes It has been known for over a decade that sialidase (neuraminidase) treatment could substantially enhance the capacity of resting B cells to stimulate the proliferation of allogeneic and antigen specific, syngeneic T cells.
T2 112-334 Sentence denotes It has been known for over a decade that sialidase (neuraminidase) treatment could substantially enhance the capacity of resting B cells to stimulate the proliferation of allogeneic and antigen specific, syngeneic T cells.
T2 112-334 Sentence denotes It has been known for over a decade that sialidase (neuraminidase) treatment could substantially enhance the capacity of resting B cells to stimulate the proliferation of allogeneic and antigen specific, syngeneic T cells.
TextSentencer_T3 335-433 Sentence denotes Thus, cell-surface sialic acid was implicated as a potential modulator of immune cell interaction.
T3 335-433 Sentence denotes Thus, cell-surface sialic acid was implicated as a potential modulator of immune cell interaction.
T3 335-433 Sentence denotes Thus, cell-surface sialic acid was implicated as a potential modulator of immune cell interaction.
TextSentencer_T4 434-839 Sentence denotes However, little progress has been made in either identifying explicit roles for sialic acid in this system or in hypothesizing mechanisms to explain the "neuraminidase effect." Here we show for the first time that cell surface sialic acid on medium incubated B cells blocks access to costimulatory molecules on the B cell surface, and that this is the most likely explanation for the neuraminidase effect.
T4 434-839 Sentence denotes However, little progress has been made in either identifying explicit roles for sialic acid in this system or in hypothesizing mechanisms to explain the "neuraminidase effect." Here we show for the first time that cell surface sialic acid on medium incubated B cells blocks access to costimulatory molecules on the B cell surface, and that this is the most likely explanation for the neuraminidase effect.
T4 434-839 Sentence denotes However, little progress has been made in either identifying explicit roles for sialic acid in this system or in hypothesizing mechanisms to explain the "neuraminidase effect." Here we show for the first time that cell surface sialic acid on medium incubated B cells blocks access to costimulatory molecules on the B cell surface, and that this is the most likely explanation for the neuraminidase effect.
TextSentencer_T5 840-1060 Sentence denotes Further, we show that it is likely to be upregulation of ICAM-1 and its subsequent engagement of LFA-1 rather than loss of cell surface sialic acid that in part regulates access to CD86 and other costimulatory molecules.
T5 840-1060 Sentence denotes Further, we show that it is likely to be upregulation of ICAM-1 and its subsequent engagement of LFA-1 rather than loss of cell surface sialic acid that in part regulates access to CD86 and other costimulatory molecules.
T5 840-1060 Sentence denotes Further, we show that it is likely to be upregulation of ICAM-1 and its subsequent engagement of LFA-1 rather than loss of cell surface sialic acid that in part regulates access to CD86 and other costimulatory molecules.
TextSentencer_T6 1061-1173 Sentence denotes However, we cannot exclude a role for CD86-bound sialic acid on the B cell in modulating binding to T cell CD28.
T6 1061-1173 Sentence denotes However, we cannot exclude a role for CD86-bound sialic acid on the B cell in modulating binding to T cell CD28.
T6 1061-1173 Sentence denotes However, we cannot exclude a role for CD86-bound sialic acid on the B cell in modulating binding to T cell CD28.
TextSentencer_T7 1174-1519 Sentence denotes Because sialidase treatment of resting B cells but not resting T cells enables T cell activation, we suggest that sialidase treatment may still be an analogue for an authentic step in B cell activation, and show that for highly activated B cells (activated with polyclonal anti-IgM plus INF-gamma) there is specific loss 2, 6-linked sialic acid.
T7 1174-1519 Sentence denotes Because sialidase treatment of resting B cells but not resting T cells enables T cell activation, we suggest that sialidase treatment may still be an analogue for an authentic step in B cell activation, and show that for highly activated B cells (activated with polyclonal anti-IgM plus INF-gamma) there is specific loss 2, 6-linked sialic acid.
T7 1174-1519 Sentence denotes Because sialidase treatment of resting B cells but not resting T cells enables T cell activation, we suggest that sialidase treatment may still be an analogue for an authentic step in B cell activation, and show that for highly activated B cells (activated with polyclonal anti-IgM plus INF-gamma) there is specific loss 2, 6-linked sialic acid.
TextSentencer_T8 1520-1608 Sentence denotes Potential roles for sialic acid in modulating B cell/T cell collaboration are discussed.
T8 1520-1608 Sentence denotes Potential roles for sialic acid in modulating B cell/T cell collaboration are discussed.
T8 1520-1608 Sentence denotes Potential roles for sialic acid in modulating B cell/T cell collaboration are discussed.