| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T887 |
0-197 |
Sentence |
denotes |
The O6-methylguanine lesion is a substrate for direct repair by O6-methylguanine-DNA methyltransferase (MGMT) (Pollack et al., 2006; Hegi et al., 2008; Fukushima et al., 2009; Zhang et al., 2012b). |
| T23 |
0-197 |
Sentence |
denotes |
The O6-methylguanine lesion is a substrate for direct repair by O6-methylguanine-DNA methyltransferase (MGMT) (Pollack et al., 2006; Hegi et al., 2008; Fukushima et al., 2009; Zhang et al., 2012b). |
| T888 |
198-446 |
Sentence |
denotes |
Without MGMT repair, O6-methylguanine initiates activation of mismatch repair-deficient (MMR) proteins or Rad3-related protein kinase that ultimately leads to apoptotic cell death (Caporali et al., 2004; Wang and Edelmann, 2006; Roos et al., 2007). |
| T24 |
198-446 |
Sentence |
denotes |
Without MGMT repair, O6-methylguanine initiates activation of mismatch repair-deficient (MMR) proteins or Rad3-related protein kinase that ultimately leads to apoptotic cell death (Caporali et al., 2004; Wang and Edelmann, 2006; Roos et al., 2007). |
| T889 |
447-618 |
Sentence |
denotes |
High expression of MGMT or loss of MMR contributes significantly to TMZ resistance in many clinical cases (Pollack et al., 2006; Hegi et al., 2008; Sarkaria et al., 2008). |
| T25 |
447-618 |
Sentence |
denotes |
High expression of MGMT or loss of MMR contributes significantly to TMZ resistance in many clinical cases (Pollack et al., 2006; Hegi et al., 2008; Sarkaria et al., 2008). |
| T890 |
619-696 |
Sentence |
denotes |
The initiation of apoptotic signaling fails in the absence of the MMR system. |
| T26 |
619-696 |
Sentence |
denotes |
The initiation of apoptotic signaling fails in the absence of the MMR system. |
