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PMC:3586680 / 19752-21580 JSONTXT 25 Projects

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Id Subject Object Predicate Lexical cue
T9760 0-112 Sentence denotes One of the unique characteristics for malignant gliomas is their diffuse infiltration into distant brain tissue.
T141 0-112 Sentence denotes One of the unique characteristics for malignant gliomas is their diffuse infiltration into distant brain tissue.
T9761 113-276 Sentence denotes Signal pathways, involving PI3K, Akt, mTOR, NF-κB, and autophagy, are believed to confer these migrating cells resistant to apoptotic death (Lefranc et al., 2005).
T142 113-276 Sentence denotes Signal pathways, involving PI3K, Akt, mTOR, NF-κB, and autophagy, are believed to confer these migrating cells resistant to apoptotic death (Lefranc et al., 2005).
T9762 277-553 Sentence denotes Glioma cells possess CD44 as a receptor for interacting with brain matrix hyaluronan (Murai et al., 2004; Yoshida et al., 2012), and secrete hyaluronidases and metalloproteinases to facilitate their migration (Delpech et al., 2002; Junker et al., 2003; Hagemann et al., 2012).
T143 277-553 Sentence denotes Glioma cells possess CD44 as a receptor for interacting with brain matrix hyaluronan (Murai et al., 2004; Yoshida et al., 2012), and secrete hyaluronidases and metalloproteinases to facilitate their migration (Delpech et al., 2002; Junker et al., 2003; Hagemann et al., 2012).
T9763 554-622 Sentence denotes Also, lack of WWOX expression is expected to enhance cell migration.
T144 554-622 Sentence denotes Also, lack of WWOX expression is expected to enhance cell migration.
T9764 623-758 Sentence denotes For example, loss of WWOX facilitates migration of ovarian cancer and osteosarcoma cells (Gourley et al., 2009; Del Mare et al., 2011).
T145 623-758 Sentence denotes For example, loss of WWOX facilitates migration of ovarian cancer and osteosarcoma cells (Gourley et al., 2009; Del Mare et al., 2011).
T9765 759-956 Sentence denotes Ectopic expression of TIAF1 (TGF-β-induced antiapoptotic factor), p53, and WWOX suppresses anchorage-independent growth and cell migration and causes apoptosis in cancer cells (Chang et al., 2012).
T146 759-956 Sentence denotes Ectopic expression of TIAF1 (TGF-β-induced antiapoptotic factor), p53, and WWOX suppresses anchorage-independent growth and cell migration and causes apoptosis in cancer cells (Chang et al., 2012).
T9766 957-1065 Sentence denotes We believe that glioma cells, with stem cell-like properties, migrate individually rather than collectively.
T147 957-1065 Sentence denotes We believe that glioma cells, with stem cell-like properties, migrate individually rather than collectively.
T9767 1066-1217 Sentence denotes This assumption is based upon our observations that mouse Wwox gene knockout cells (e.g., embryonic fibroblasts) migrate individually and aggressively.
T148 1066-1217 Sentence denotes This assumption is based upon our observations that mouse Wwox gene knockout cells (e.g., embryonic fibroblasts) migrate individually and aggressively.
T9768 1218-1295 Sentence denotes In contrast, wild type cells migrate collectively (Chou et al., unpublished).
T149 1218-1295 Sentence denotes In contrast, wild type cells migrate collectively (Chou et al., unpublished).
T9769 1296-1534 Sentence denotes While a portion of WWOX is anchored on the cell membrane/cytoskeleton, WWOX-negative cells lose recognition by parental WWOX-positive cells, and this increases the mobility of WWOX-negative cells to move away from the WWOX-positive cells.
T150 1296-1534 Sentence denotes While a portion of WWOX is anchored on the cell membrane/cytoskeleton, WWOX-negative cells lose recognition by parental WWOX-positive cells, and this increases the mobility of WWOX-negative cells to move away from the WWOX-positive cells.
T9770 1535-1672 Sentence denotes Conceivably, WWOX-negative glioma cells migrate individually and turn away from WWOX-expressing brain cells to low WWOX expression areas.
T151 1535-1672 Sentence denotes Conceivably, WWOX-negative glioma cells migrate individually and turn away from WWOX-expressing brain cells to low WWOX expression areas.
T9771 1673-1828 Sentence denotes Apparently, the migratory behavior of WWOX-negative glioma cells may account for the diffuse invasion into distant brain tissue (Chou et al., unpublished).
T152 1673-1828 Sentence denotes Apparently, the migratory behavior of WWOX-negative glioma cells may account for the diffuse invasion into distant brain tissue (Chou et al., unpublished).