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PMC:3586680 / 18673-19751 JSONTXT 23 Projects

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Id Subject Object Predicate Lexical cue
T9752 0-120 Sentence denotes Failure of ectopic WWOX in inducing apoptosis of glioma cells possessing wild type p53 is unusual (Chiang et al., 2012).
T133 0-120 Sentence denotes Failure of ectopic WWOX in inducing apoptosis of glioma cells possessing wild type p53 is unusual (Chiang et al., 2012).
T9753 121-323 Sentence denotes In most cases, we have shown that p53 functionally interacts with WWOX, and both proteins induce apoptosis in a synergistic manner (Chang et al., 2001, 2003, 2005a,b, 2007, 2010, 2012; Su et al., 2012).
T134 121-323 Sentence denotes In most cases, we have shown that p53 functionally interacts with WWOX, and both proteins induce apoptosis in a synergistic manner (Chang et al., 2001, 2003, 2005a,b, 2007, 2010, 2012; Su et al., 2012).
T9754 324-457 Sentence denotes A likely scenario is that p53-binding proteins, which are present in GBMs, may interfere with the apoptotic function of WWOX and p53.
T135 324-457 Sentence denotes A likely scenario is that p53-binding proteins, which are present in GBMs, may interfere with the apoptotic function of WWOX and p53.
T9755 458-548 Sentence denotes Functional antagonism among tumor suppressors has never been documented in the literature.
T136 458-548 Sentence denotes Functional antagonism among tumor suppressors has never been documented in the literature.
T9756 549-791 Sentence denotes However, it is not surprising to find that many tumor suppressor proteins, e.g., p53, WWOX, Smad4, PTEN, PP2A, and etc., are significantly upregulated during the early stage of cancer progression (Lai et al., 2005; Chang et al., unpublished).
T137 549-791 Sentence denotes However, it is not surprising to find that many tumor suppressor proteins, e.g., p53, WWOX, Smad4, PTEN, PP2A, and etc., are significantly upregulated during the early stage of cancer progression (Lai et al., 2005; Chang et al., unpublished).
T9757 792-889 Sentence denotes Do these proteins act synergistically in blocking cancer progression but lose control eventually?
T138 792-889 Sentence denotes Do these proteins act synergistically in blocking cancer progression but lose control eventually?
T9758 890-964 Sentence denotes Or, do they counteract each other’s function, thus allowing cancer growth?
T139 890-964 Sentence denotes Or, do they counteract each other’s function, thus allowing cancer growth?
T9759 965-1078 Sentence denotes Whether endogenous WWOX counteracts with the function of endogenous p53 is unknown and remains to be established.
T140 965-1078 Sentence denotes Whether endogenous WWOX counteracts with the function of endogenous p53 is unknown and remains to be established.