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PMC:3586680 / 16274-17662 JSONTXT 24 Projects

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Id Subject Object Predicate Lexical cue
T8399 0-162 Sentence denotes Altered WWOX expression is shown in GBMs, in which downregulation of WWOX is associated with loss of heterozygosity and promoter methylation (Kosla et al., 2011).
T112 0-162 Sentence denotes Altered WWOX expression is shown in GBMs, in which downregulation of WWOX is associated with loss of heterozygosity and promoter methylation (Kosla et al., 2011).
T8400 163-348 Sentence denotes Recently, we demonstrated that overexpressed WWOX induces apoptosis of glioblastoma U373-MG cells harboring mutant p53 by causing hypoploidy and DNA fragmentation (Chiang et al., 2012).
T113 163-348 Sentence denotes Recently, we demonstrated that overexpressed WWOX induces apoptosis of glioblastoma U373-MG cells harboring mutant p53 by causing hypoploidy and DNA fragmentation (Chiang et al., 2012).
T8401 349-422 Sentence denotes However, ectopic WWOX has no effect with U87-MG expressing wild type p53.
T114 349-422 Sentence denotes However, ectopic WWOX has no effect with U87-MG expressing wild type p53.
T8402 423-562 Sentence denotes Unlike TMZ, WWOX induces apoptosis of U373-MG cells via a mitochondria-independent and caspase-3-independent pathway (Chiang et al., 2012).
T115 423-562 Sentence denotes Unlike TMZ, WWOX induces apoptosis of U373-MG cells via a mitochondria-independent and caspase-3-independent pathway (Chiang et al., 2012).
T8403 563-760 Sentence denotes While the underlying mechanisms are unknown, it is reasonable to assume that the survival of human glioblastoma cells depends upon interactions between the gain-of-function of p53 mutants and WWOX.
T116 563-760 Sentence denotes While the underlying mechanisms are unknown, it is reasonable to assume that the survival of human glioblastoma cells depends upon interactions between the gain-of-function of p53 mutants and WWOX.
T8404 761-845 Sentence denotes Activated WWOX binds wild type p53 with Ser46 phosphorylation (Chang et al., 2005b).
T117 761-845 Sentence denotes Activated WWOX binds wild type p53 with Ser46 phosphorylation (Chang et al., 2005b).
T8405 846-895 Sentence denotes UV irradiation enhances the binding interactions.
T118 846-895 Sentence denotes UV irradiation enhances the binding interactions.
T8406 896-996 Sentence denotes Despite the presence of Ser46 in Δ40p53, binding of this protein with WWOX remains to be determined.
T119 896-996 Sentence denotes Despite the presence of Ser46 in Δ40p53, binding of this protein with WWOX remains to be determined.
T8407 997-1188 Sentence denotes We postulate that in GBM cells, both wild type p53 and ectopic WWOX proteins appear to have a functional antagonism, thereby nullifying each other’s function in inducing apoptosis (Figure 2).
T120 997-1188 Sentence denotes We postulate that in GBM cells, both wild type p53 and ectopic WWOX proteins appear to have a functional antagonism, thereby nullifying each other’s function in inducing apoptosis (Figure 2).
T8408 1189-1285 Sentence denotes Mutant p53 proteins cannot bind ectopic WWOX in GBM cells, and WWOX is able to induce apoptosis.
T121 1189-1285 Sentence denotes Mutant p53 proteins cannot bind ectopic WWOX in GBM cells, and WWOX is able to induce apoptosis.
T8409 1286-1388 Sentence denotes Whether WWOX causes apoptosis in GBM expressing p53 isoforms is unknown and remains to be established.
T122 1286-1388 Sentence denotes Whether WWOX causes apoptosis in GBM expressing p53 isoforms is unknown and remains to be established.