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PMC:3586680 / 15819-17662 JSONTXT 24 Projects

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Id Subject Object Predicate Lexical cue
T109 0-32 Sentence denotes p53 and WWOX Alterations in GBMs
T8397 33-244 Sentence denotes p53 mutants are considered as unfavorable factors for the effectiveness in radiotherapy and TMZ treatment in glioma cells (Gjerset et al., 1995; Hirose et al., 2001; Squatrito et al., 2010; Blough et al., 2011).
T110 33-244 Sentence denotes p53 mutants are considered as unfavorable factors for the effectiveness in radiotherapy and TMZ treatment in glioma cells (Gjerset et al., 1995; Hirose et al., 2001; Squatrito et al., 2010; Blough et al., 2011).
T8398 245-454 Sentence denotes Loss of functional p53 confers sensitivity to TMZ in glioma cells, whereas wild type p53 increases the TMZ resistance (Blough et al., 2011). p53 mutants reduce TMZ sensitivity in gliomas (Blough et al., 2011).
T111 245-454 Sentence denotes Loss of functional p53 confers sensitivity to TMZ in glioma cells, whereas wild type p53 increases the TMZ resistance (Blough et al., 2011). p53 mutants reduce TMZ sensitivity in gliomas (Blough et al., 2011).
T8399 455-617 Sentence denotes Altered WWOX expression is shown in GBMs, in which downregulation of WWOX is associated with loss of heterozygosity and promoter methylation (Kosla et al., 2011).
T112 455-617 Sentence denotes Altered WWOX expression is shown in GBMs, in which downregulation of WWOX is associated with loss of heterozygosity and promoter methylation (Kosla et al., 2011).
T8400 618-803 Sentence denotes Recently, we demonstrated that overexpressed WWOX induces apoptosis of glioblastoma U373-MG cells harboring mutant p53 by causing hypoploidy and DNA fragmentation (Chiang et al., 2012).
T113 618-803 Sentence denotes Recently, we demonstrated that overexpressed WWOX induces apoptosis of glioblastoma U373-MG cells harboring mutant p53 by causing hypoploidy and DNA fragmentation (Chiang et al., 2012).
T8401 804-877 Sentence denotes However, ectopic WWOX has no effect with U87-MG expressing wild type p53.
T114 804-877 Sentence denotes However, ectopic WWOX has no effect with U87-MG expressing wild type p53.
T8402 878-1017 Sentence denotes Unlike TMZ, WWOX induces apoptosis of U373-MG cells via a mitochondria-independent and caspase-3-independent pathway (Chiang et al., 2012).
T115 878-1017 Sentence denotes Unlike TMZ, WWOX induces apoptosis of U373-MG cells via a mitochondria-independent and caspase-3-independent pathway (Chiang et al., 2012).
T8403 1018-1215 Sentence denotes While the underlying mechanisms are unknown, it is reasonable to assume that the survival of human glioblastoma cells depends upon interactions between the gain-of-function of p53 mutants and WWOX.
T116 1018-1215 Sentence denotes While the underlying mechanisms are unknown, it is reasonable to assume that the survival of human glioblastoma cells depends upon interactions between the gain-of-function of p53 mutants and WWOX.
T8404 1216-1300 Sentence denotes Activated WWOX binds wild type p53 with Ser46 phosphorylation (Chang et al., 2005b).
T117 1216-1300 Sentence denotes Activated WWOX binds wild type p53 with Ser46 phosphorylation (Chang et al., 2005b).
T8405 1301-1350 Sentence denotes UV irradiation enhances the binding interactions.
T118 1301-1350 Sentence denotes UV irradiation enhances the binding interactions.
T8406 1351-1451 Sentence denotes Despite the presence of Ser46 in Δ40p53, binding of this protein with WWOX remains to be determined.
T119 1351-1451 Sentence denotes Despite the presence of Ser46 in Δ40p53, binding of this protein with WWOX remains to be determined.
T8407 1452-1643 Sentence denotes We postulate that in GBM cells, both wild type p53 and ectopic WWOX proteins appear to have a functional antagonism, thereby nullifying each other’s function in inducing apoptosis (Figure 2).
T120 1452-1643 Sentence denotes We postulate that in GBM cells, both wild type p53 and ectopic WWOX proteins appear to have a functional antagonism, thereby nullifying each other’s function in inducing apoptosis (Figure 2).
T8408 1644-1740 Sentence denotes Mutant p53 proteins cannot bind ectopic WWOX in GBM cells, and WWOX is able to induce apoptosis.
T121 1644-1740 Sentence denotes Mutant p53 proteins cannot bind ectopic WWOX in GBM cells, and WWOX is able to induce apoptosis.
T8409 1741-1843 Sentence denotes Whether WWOX causes apoptosis in GBM expressing p53 isoforms is unknown and remains to be established.
T122 1741-1843 Sentence denotes Whether WWOX causes apoptosis in GBM expressing p53 isoforms is unknown and remains to be established.