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PMC:3586680 / 14835-15817 JSONTXT 23 Projects

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Id Subject Object Predicate Lexical cue
T103 0-12 Sentence denotes p53 Isoforms
T7491 13-220 Sentence denotes At least nine isoforms of p53 have been identified due to alternative mRNA splicing, multiple gene promoters, and alternative initiation sites of translation (Ghosh et al., 2004; Ray et al., 2006; Figure 2).
T104 13-220 Sentence denotes At least nine isoforms of p53 have been identified due to alternative mRNA splicing, multiple gene promoters, and alternative initiation sites of translation (Ghosh et al., 2004; Ray et al., 2006; Figure 2).
T7492 221-325 Sentence denotes In cancers, aberrant expression of p53 isoforms occurs frequently (Bourdon et al., 2005; Bourdon, 2007).
T105 221-325 Sentence denotes In cancers, aberrant expression of p53 isoforms occurs frequently (Bourdon et al., 2005; Bourdon, 2007).
T7493 326-561 Sentence denotes Full-length p53, Δ133p53, and p53β are localized mainly in the nucleus, and only few of them are in cytoplasm. p53γ and Δ133p53β are localized in the nucleus and cytoplasm. Δ133p53γ is localized in the cytoplasm (Bourdon et al., 2005).
T106 326-561 Sentence denotes Full-length p53, Δ133p53, and p53β are localized mainly in the nucleus, and only few of them are in cytoplasm. p53γ and Δ133p53β are localized in the nucleus and cytoplasm. Δ133p53γ is localized in the cytoplasm (Bourdon et al., 2005).
T7494 562-842 Sentence denotes Co-transfection of p53 and p53β increases p53-mediated apoptosis, whereas co-expression of p53 with Δ133p53 suppresses p53-mediated apoptosis (Bourdon et al., 2005). Δ133p53 differentially regulates gene expression in p53-dependent and -independent manners (Aoubala et al., 2011).
T107 562-842 Sentence denotes Co-transfection of p53 and p53β increases p53-mediated apoptosis, whereas co-expression of p53 with Δ133p53 suppresses p53-mediated apoptosis (Bourdon et al., 2005). Δ133p53 differentially regulates gene expression in p53-dependent and -independent manners (Aoubala et al., 2011).
T7495 843-982 Sentence denotes Co-expression of Δ133p53β or Δ133p53γ with p53 does not affect p53 transcriptional activity on p21 and Bax promoters, as well as apoptosis.
T108 843-982 Sentence denotes Co-expression of Δ133p53β or Δ133p53γ with p53 does not affect p53 transcriptional activity on p21 and Bax promoters, as well as apoptosis.