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PMC:3586680 / 13720-14833 JSONTXT 23 Projects

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Id Subject Object Predicate Lexical cue
T14072 0-279 Sentence denotes p53 and WWOX in GBM cell apoptosis. (A) Full-length p53 possesses two N-terminal transactivation acidic domains, a proline-rich domain, a central DNA-binding region, and a C-terminal domain, containing a nuclear localization signal, an oligomerization domain, and a basic region.
T14073 280-415 Sentence denotes N-terminal deletion mutants of p53 are also shown. (B) Three likely scenarios are proposed for WWOX and p53 to regulate GBM cell death.
T95 280-415 Sentence denotes N-terminal deletion mutants of p53 are also shown. (B) Three likely scenarios are proposed for WWOX and p53 to regulate GBM cell death.
T14074 416-511 Sentence denotes First, ectopic WWOX fails to induce apoptosis of GBM cells expressing endogenous wild type p53.
T96 416-511 Sentence denotes First, ectopic WWOX fails to induce apoptosis of GBM cells expressing endogenous wild type p53.
T14075 512-651 Sentence denotes It appears that ectopic WWOX binds and functionally antagonizes p53, and both proteins nullify each other’s function in inducing apoptosis.
T97 512-651 Sentence denotes It appears that ectopic WWOX binds and functionally antagonizes p53, and both proteins nullify each other’s function in inducing apoptosis.
T14076 652-748 Sentence denotes Second, no physical interactions between mutant p53 proteins and WWOX are expected in GBM cells.
T98 652-748 Sentence denotes Second, no physical interactions between mutant p53 proteins and WWOX are expected in GBM cells.
T14077 749-816 Sentence denotes Thus, ectopic WWOX induce apoptosis in mutant p53-expressing cells.
T99 749-816 Sentence denotes Thus, ectopic WWOX induce apoptosis in mutant p53-expressing cells.
T14078 817-869 Sentence denotes Finally, whether WWOX binds p53 isoforms is unknown.
T100 817-869 Sentence denotes Finally, whether WWOX binds p53 isoforms is unknown.
T14079 870-983 Sentence denotes Also, whether ectopic WWOX induction of apoptosis in GBM cells expressing p53 isoforms remains to be established.
T101 870-983 Sentence denotes Also, whether ectopic WWOX induction of apoptosis in GBM cells expressing p53 isoforms remains to be established.
T14080 984-1113 Sentence denotes TAD, transactivation domain; PrD, proline domain; NLS, nuclear localization signal; OD, oligomerization domain; BR, basic region.
T102 984-1113 Sentence denotes TAD, transactivation domain; PrD, proline domain; NLS, nuclear localization signal; OD, oligomerization domain; BR, basic region.