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PMC:3359311 / 15230-16298 JSONTXT 13 Projects

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Id Subject Object Predicate Lexical cue
T5207 0-69 Sentence denotes Bay11-7082 inhibits pro-IL-1β production in response to P. aeruginosa
T105 0-69 Sentence denotes Bay11-7082 inhibits pro-IL-1β production in response to P. aeruginosa
T5208 71-181 Sentence denotes In addition to inhibition of NF-κB activity, Bay11-7082 can also directly inhibit the NLRP3 inflammasome [38].
T106 71-181 Sentence denotes In addition to inhibition of NF-κB activity, Bay11-7082 can also directly inhibit the NLRP3 inflammasome [38].
T5209 182-393 Sentence denotes To validate its use in this study as an NF-κB inhibitor, western blots for pro-IL-1β were performed alongside inhibition of CFTR activity by CFTRinh172 in response to PAO1 at 4 hours after stimulation (Fig. 7a).
T107 182-393 Sentence denotes To validate its use in this study as an NF-κB inhibitor, western blots for pro-IL-1β were performed alongside inhibition of CFTR activity by CFTRinh172 in response to PAO1 at 4 hours after stimulation (Fig. 7a).
T5210 394-510 Sentence denotes Our results indicate that Bay11-7082 prevents production of pro-IL-1β whereas CFTRinh172 does not seem to affect it.
T108 394-510 Sentence denotes Our results indicate that Bay11-7082 prevents production of pro-IL-1β whereas CFTRinh172 does not seem to affect it.
T5211 511-652 Sentence denotes This was further corroborated by the ability Bay11-7082 to inhibit IκBα degradation at 0.5, 1, and 1.5 hours post PAO1 stimulation (Fig. 7b).
T109 511-652 Sentence denotes This was further corroborated by the ability Bay11-7082 to inhibit IκBα degradation at 0.5, 1, and 1.5 hours post PAO1 stimulation (Fig. 7b).
T110 653-767 Sentence denotes 10.1371/journal.pone.0037689.g007 Figure 7 Bay11-7082 inhibits pro-IL-1β production in response to P. aeruginosa.
T14502 697-767 Sentence denotes Bay11-7082 inhibits pro-IL-1β production in response to P. aeruginosa.
T14503 768-953 Sentence denotes PMA-differentiated THP-1 cells were treated with 10 µM CFTRinh172 or 20 µM Bay11-7082 and harvested after (A) 4 hours (n = 3) or (B) 0.5, 1, and 1.5 hours (n = 3) stimulation with PAO1.
T111 768-953 Sentence denotes PMA-differentiated THP-1 cells were treated with 10 µM CFTRinh172 or 20 µM Bay11-7082 and harvested after (A) 4 hours (n = 3) or (B) 0.5, 1, and 1.5 hours (n = 3) stimulation with PAO1.
T14504 954-1065 Sentence denotes One representative blot is shown with a graph of the averaged fluorescence intensity values over 3 experiments.
T112 954-1065 Sentence denotes One representative blot is shown with a graph of the averaged fluorescence intensity values over 3 experiments.