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PMC:3317373 / 16892-18095 JSONTXT 24 Projects

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Id Subject Object Predicate Lexical cue
T7223 0-177 Sentence denotes Nrf2-ARE pathway has been proved to be the key regulator in reducing oxidative stress, inflammatory damage, and accumulation of toxic metabolites, which are all involved in TBI.
T169 0-177 Sentence denotes Nrf2-ARE pathway has been proved to be the key regulator in reducing oxidative stress, inflammatory damage, and accumulation of toxic metabolites, which are all involved in TBI.
T7224 178-264 Sentence denotes Our previous study has proved the augmentation of Nrf2 in brain tissue after TBI [17].
T170 178-264 Sentence denotes Our previous study has proved the augmentation of Nrf2 in brain tissue after TBI [17].
T7225 265-481 Sentence denotes Enhanced level of Nrf2 activates transcription of a group of antioxidant genes, such as heme oxygenase-1 (HO-1) and NAD (P)H: quinone oxidoreductase-1 (NQO1), which would subsequently reduce the damage in brain [18].
T171 265-481 Sentence denotes Enhanced level of Nrf2 activates transcription of a group of antioxidant genes, such as heme oxygenase-1 (HO-1) and NAD (P)H: quinone oxidoreductase-1 (NQO1), which would subsequently reduce the damage in brain [18].
T7226 482-743 Sentence denotes Postinjury administration of SFN, an inducer of Nrf2, significantly improves spatial memory of rat and decreases the immunoreactivity for 4-Hydroxynonenal (4-HNE), a marker of lipid peroxidation, in the cortex and the CA3 subfield of hippocampus after TBI [19].
T172 482-743 Sentence denotes Postinjury administration of SFN, an inducer of Nrf2, significantly improves spatial memory of rat and decreases the immunoreactivity for 4-Hydroxynonenal (4-HNE), a marker of lipid peroxidation, in the cortex and the CA3 subfield of hippocampus after TBI [19].
T7227 744-814 Sentence denotes On the other hand, Nrf2-deficient mice appear more susceptible to TBI.
T173 744-814 Sentence denotes On the other hand, Nrf2-deficient mice appear more susceptible to TBI.
T7228 815-912 Sentence denotes Depletion of Nrf2 induces higher expression of proinflammatory mediators in brain after TBI [20].
T174 815-912 Sentence denotes Depletion of Nrf2 induces higher expression of proinflammatory mediators in brain after TBI [20].
T7229 913-1203 Sentence denotes Here, our results revealed that overexpression of TNF-α, IL-1β, IL-6, and MMP9 after scratch injury was more aggravated in cultured Nrf2 knockout astrocytes than in wildtype astrocyetes for the first time, and overexpression of these proinflammatory mediators led to more astrocytes deaths.
T175 913-1203 Sentence denotes Here, our results revealed that overexpression of TNF-α, IL-1β, IL-6, and MMP9 after scratch injury was more aggravated in cultured Nrf2 knockout astrocytes than in wildtype astrocyetes for the first time, and overexpression of these proinflammatory mediators led to more astrocytes deaths.