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PMC:3317373 / 130-1289 JSONTXT 23 Projects

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Id Subject Object Predicate Lexical cue
T25 0-211 Sentence denotes It has been proved that Nrf2 depletion enhances inflammatory process through activation of NF-κB in the brain after TBI, but little is known about the relationship between Nrf2 and NF-κB in astrocytes after TBI.
T3 0-211 Sentence denotes It has been proved that Nrf2 depletion enhances inflammatory process through activation of NF-κB in the brain after TBI, but little is known about the relationship between Nrf2 and NF-κB in astrocytes after TBI.
T26 212-427 Sentence denotes Hence, we used primary cultured astrocytes from either Nrf2 wildtype or knockout mice to study the influence of Nrf2 on the activation of NF-κB and expression of proinflammatory cytokines in a model of TBI in vitro.
T4 212-427 Sentence denotes Hence, we used primary cultured astrocytes from either Nrf2 wildtype or knockout mice to study the influence of Nrf2 on the activation of NF-κB and expression of proinflammatory cytokines in a model of TBI in vitro.
T27 428-510 Sentence denotes Primary cultured astrocytes were scratched to mimic the traumatic injury in vitro.
T5 428-510 Sentence denotes Primary cultured astrocytes were scratched to mimic the traumatic injury in vitro.
T28 511-572 Sentence denotes Then the DNA-binding activity of NF-κB was evaluated by EMSA.
T6 511-572 Sentence denotes Then the DNA-binding activity of NF-κB was evaluated by EMSA.
T29 573-653 Sentence denotes The mRNA and protein levels of TNF-α, IL-1β, IL-6, and MMP9 were also evaluated.
T7 573-653 Sentence denotes The mRNA and protein levels of TNF-α, IL-1β, IL-6, and MMP9 were also evaluated.
T30 654-718 Sentence denotes Gelatin zymography was performed to detect the activity of MMP9.
T8 654-718 Sentence denotes Gelatin zymography was performed to detect the activity of MMP9.
T31 719-840 Sentence denotes The activity of NF-κB and expression of proinflammatory cytokines mentioned above were upregulated at 24 h after scratch.
T9 719-840 Sentence denotes The activity of NF-κB and expression of proinflammatory cytokines mentioned above were upregulated at 24 h after scratch.
T32 841-896 Sentence denotes The expression and activity of MMP9 were also elevated.
T10 841-896 Sentence denotes The expression and activity of MMP9 were also elevated.
T33 897-988 Sentence denotes And such tendency was much more prominent in Nrf2 KO astrocytes than that in WT astrocytes.
T11 897-988 Sentence denotes And such tendency was much more prominent in Nrf2 KO astrocytes than that in WT astrocytes.
T34 989-1159 Sentence denotes These results suggest that the absence of Nrf2 may induce more aggressive inflammation through activation of NF-κB and downstream proinflammatory cytokines in astrocytes.
T12 989-1159 Sentence denotes These results suggest that the absence of Nrf2 may induce more aggressive inflammation through activation of NF-κB and downstream proinflammatory cytokines in astrocytes.