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PMC:3317373 / 1291-2851 JSONTXT 13 Projects

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Id Subject Object Predicate Lexical cue
T13 0-2 Sentence denotes 1.
T14 3-15 Sentence denotes Introduction
T620 16-149 Sentence denotes Brain damage following traumatic injury is a result of direct (primary injury) and indirect (secondary or delayed injury) mechanisms.
T15 16-149 Sentence denotes Brain damage following traumatic injury is a result of direct (primary injury) and indirect (secondary or delayed injury) mechanisms.
T621 150-494 Sentence denotes The secondary injury mechanism involves the initiation of an acute inflammatory response, including breakdown of blood-brain barrier (BBB), brain edema, infiltration of peripheral blood cells, and activation of resident immunocompetent cells, as well as the release of numerous immune mediators such as interleukins and chemotactic factors [1].
T16 150-494 Sentence denotes The secondary injury mechanism involves the initiation of an acute inflammatory response, including breakdown of blood-brain barrier (BBB), brain edema, infiltration of peripheral blood cells, and activation of resident immunocompetent cells, as well as the release of numerous immune mediators such as interleukins and chemotactic factors [1].
T622 495-602 Sentence denotes And the subsequent inflammation leads to secondary damage not only in brain but also in other organs [2–4].
T17 495-602 Sentence denotes And the subsequent inflammation leads to secondary damage not only in brain but also in other organs [2–4].
T623 603-726 Sentence denotes Nuclear factor erythroid 2-related factor2 (Nrf2) is a transcription factor that regulates many kinds of antioxidant genes.
T18 603-726 Sentence denotes Nuclear factor erythroid 2-related factor2 (Nrf2) is a transcription factor that regulates many kinds of antioxidant genes.
T624 727-846 Sentence denotes Several studies have demonstrated that Nrf2 regulates the inflammation in the brain after traumatic brain injury (TBI).
T19 727-846 Sentence denotes Several studies have demonstrated that Nrf2 regulates the inflammation in the brain after traumatic brain injury (TBI).
T625 847-959 Sentence denotes It was also showed that TBI could induce more aggravated damage in Nrf2 knockout mice than in wildtype mice [5].
T20 847-959 Sentence denotes It was also showed that TBI could induce more aggravated damage in Nrf2 knockout mice than in wildtype mice [5].
T626 960-1097 Sentence denotes On the contrary, such inflammation can be extenuated through elevating the level of Nrf2 by its inducers, such as sulforaphane (SFN) [6].
T21 960-1097 Sentence denotes On the contrary, such inflammation can be extenuated through elevating the level of Nrf2 by its inducers, such as sulforaphane (SFN) [6].
T627 1098-1232 Sentence denotes It is well documented that astrocytes play a critical role in maintaining normal brain physiology and responding to injury or disease.
T22 1098-1232 Sentence denotes It is well documented that astrocytes play a critical role in maintaining normal brain physiology and responding to injury or disease.
T628 1233-1295 Sentence denotes In fact, all the aforementioned studies are performed in vivo.
T23 1233-1295 Sentence denotes In fact, all the aforementioned studies are performed in vivo.
T629 1296-1389 Sentence denotes Little is known about the relationship between Nrf2 and inflammation in astrocytes after TBI.
T24 1296-1389 Sentence denotes Little is known about the relationship between Nrf2 and inflammation in astrocytes after TBI.
T630 1390-1560 Sentence denotes Therefore, here we analysed the influence of Nrf2 on the expression of proinflammatory cytokines in primary cultured astrocytes from transgenic mice after scratch injury.
T25 1390-1560 Sentence denotes Therefore, here we analysed the influence of Nrf2 on the expression of proinflammatory cytokines in primary cultured astrocytes from transgenic mice after scratch injury.