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PMC:3317373 / 12737-14463 JSONTXT 25 Projects

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Id Subject Object Predicate Lexical cue
T5417 0-4 Sentence denotes 3.3.
T135 0-4 Sentence denotes 3.3.
T5418 5-106 Sentence denotes Expression of Proinflammatory Cytokines Was Elevated in Nrf2 Knockout Astrocytes after Scratch Injury
T136 5-106 Sentence denotes Expression of Proinflammatory Cytokines Was Elevated in Nrf2 Knockout Astrocytes after Scratch Injury
T5419 107-214 Sentence denotes As we all know, TNF-α, IL-1β, and IL-6 are regulated by NF-κB and reflect the endogenous activity of NF-κB.
T137 107-214 Sentence denotes As we all know, TNF-α, IL-1β, and IL-6 are regulated by NF-κB and reflect the endogenous activity of NF-κB.
T5420 215-315 Sentence denotes It has been revealed that these proinflammatory cytokines are increased after TBI in animals [2, 8].
T138 215-315 Sentence denotes It has been revealed that these proinflammatory cytokines are increased after TBI in animals [2, 8].
T5421 316-467 Sentence denotes And our previous study has proved that higher levels of such proinflammatory cytokines were observed in the brain of Nrf2-deficient mice after TBI [5].
T139 316-467 Sentence denotes And our previous study has proved that higher levels of such proinflammatory cytokines were observed in the brain of Nrf2-deficient mice after TBI [5].
T5422 468-574 Sentence denotes But it is still ambiguous about the relationship between these cytokines and Nrf2 in astrocytes after TBI.
T140 468-574 Sentence denotes But it is still ambiguous about the relationship between these cytokines and Nrf2 in astrocytes after TBI.
T5423 575-700 Sentence denotes Here, we tested the levels of TNF-α, IL-1β, and IL-6 in cultured astrocytes at 24 h after scratch injury by RT-PCR and ELISA.
T141 575-700 Sentence denotes Here, we tested the levels of TNF-α, IL-1β, and IL-6 in cultured astrocytes at 24 h after scratch injury by RT-PCR and ELISA.
T5424 701-876 Sentence denotes It was shown that the mRNA levels of TNF-α, IL-1β, and IL-6 were increased after scratch in both WT and KO astrocytes when compared with their sham counterparts, respectively.
T142 701-876 Sentence denotes It was shown that the mRNA levels of TNF-α, IL-1β, and IL-6 were increased after scratch in both WT and KO astrocytes when compared with their sham counterparts, respectively.
T5425 877-1117 Sentence denotes Moreover, the mRNA levels of these cytokines in group KO TBI were much higher than those in group WT TBI (1.66 ± 0.085 versus 1.39 ± 0.110 for TNF-α, 1.34 ± 0.064 versus 0.73 ± 0.088 for IL-1β, and 1.28 ± 0.102 versus 0.99 ± 0.073 for IL-6.
T143 877-1117 Sentence denotes Moreover, the mRNA levels of these cytokines in group KO TBI were much higher than those in group WT TBI (1.66 ± 0.085 versus 1.39 ± 0.110 for TNF-α, 1.34 ± 0.064 versus 0.73 ± 0.088 for IL-1β, and 1.28 ± 0.102 versus 0.99 ± 0.073 for IL-6.
T5426 1118-1148 Sentence denotes P < 0.01) (Figures 3(a)–3(d)).
T144 1118-1148 Sentence denotes P < 0.01) (Figures 3(a)–3(d)).
T5427 1149-1315 Sentence denotes The results of ELISA revealed that the protein level of TNF-α was upregulated after scratch injury in WT and KO astrocytes when compared with their sham counterparts.
T145 1149-1315 Sentence denotes The results of ELISA revealed that the protein level of TNF-α was upregulated after scratch injury in WT and KO astrocytes when compared with their sham counterparts.
T5428 1316-1435 Sentence denotes And it was also higher in group KO TBI than in group WT TBI (3.67 ± 0.156 versus 2.31 ± 0.087, P < 0.01) (Figure 4(a)).
T146 1316-1435 Sentence denotes And it was also higher in group KO TBI than in group WT TBI (3.67 ± 0.156 versus 2.31 ± 0.087, P < 0.01) (Figure 4(a)).
T5429 1436-1501 Sentence denotes Similar tendency was observed in protein level of IL-6 and IL-1β.
T147 1436-1501 Sentence denotes Similar tendency was observed in protein level of IL-6 and IL-1β.
T5430 1502-1612 Sentence denotes For IL-6, it was 36.07 ± 0.786 for group KO TBI while 25.76 ± 0.536 for group WT TBI (P < 0.01) (Figure 4(b)).
T148 1502-1612 Sentence denotes For IL-6, it was 36.07 ± 0.786 for group KO TBI while 25.76 ± 0.536 for group WT TBI (P < 0.01) (Figure 4(b)).
T5431 1613-1726 Sentence denotes For IL-1β, it was 190.75 ± 6.339 for group KO TBI while 154.50 ± 5.348 for group WT TBI (P < 0.01) (Figure 4(c)).
T149 1613-1726 Sentence denotes For IL-1β, it was 190.75 ± 6.339 for group KO TBI while 154.50 ± 5.348 for group WT TBI (P < 0.01) (Figure 4(c)).