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PMC:3312845 / 28482-29962 JSONTXT 24 Projects

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Id Subject Object Predicate Lexical cue
T11625 0-235 Sentence denotes The major findings in the present study are that TNF-α signaling showed cellular specific responses of NF-κB phosphorylation in the PC following SE, which may be related to vasogenic edema formation followed by neutrophil infiltration.
T210 0-235 Sentence denotes The major findings in the present study are that TNF-α signaling showed cellular specific responses of NF-κB phosphorylation in the PC following SE, which may be related to vasogenic edema formation followed by neutrophil infiltration.
T11626 236-321 Sentence denotes BBB disruption has been reported in experimental and human epilepsy [12,13,15,16,28].
T211 236-321 Sentence denotes BBB disruption has been reported in experimental and human epilepsy [12,13,15,16,28].
T11627 322-459 Sentence denotes Leakage of serum-derived components into the extracellular space is associated with hyperexcitability and seizure onset [12,13,15,16,28].
T212 322-459 Sentence denotes Leakage of serum-derived components into the extracellular space is associated with hyperexcitability and seizure onset [12,13,15,16,28].
T11628 460-581 Sentence denotes Furthermore, dysfunction of the BBB leads to epileptogenesis and contributes to progression of epilepsy [12,13,15,16,28].
T213 460-581 Sentence denotes Furthermore, dysfunction of the BBB leads to epileptogenesis and contributes to progression of epilepsy [12,13,15,16,28].
T11629 582-686 Sentence denotes In the present study, TNF-α immunoreactivity was obviously observed in microglia in the PC following SE.
T214 582-686 Sentence denotes In the present study, TNF-α immunoreactivity was obviously observed in microglia in the PC following SE.
T11630 687-803 Sentence denotes TNF receptor expressions were also up-regulated in astrocytes (TNFp55R and TNFp75R) and endothelial cells (TNFp75R).
T215 687-803 Sentence denotes TNF receptor expressions were also up-regulated in astrocytes (TNFp55R and TNFp75R) and endothelial cells (TNFp75R).
T11631 804-974 Sentence denotes Furthermore, blockade of TNF-α signaling by sTNFp55 infusion effectively (but not completely) reduced volumes of SE-induced vasogenic edema and neuronal damage in the PC.
T216 804-974 Sentence denotes Furthermore, blockade of TNF-α signaling by sTNFp55 infusion effectively (but not completely) reduced volumes of SE-induced vasogenic edema and neuronal damage in the PC.
T11632 975-1138 Sentence denotes These findings indicate that TNF-α may participate in astroglial and endothelial responses to SE, which are relevant to SE-induced vasogenic edema formation [5-8].
T217 975-1138 Sentence denotes These findings indicate that TNF-α may participate in astroglial and endothelial responses to SE, which are relevant to SE-induced vasogenic edema formation [5-8].
T11633 1139-1234 Sentence denotes Indeed, TNF-α signaling increases BBB permeability in various experimental disease models [29].
T218 1139-1234 Sentence denotes Indeed, TNF-α signaling increases BBB permeability in various experimental disease models [29].
T11634 1235-1360 Sentence denotes In the present study, sTNFp55 infusion could not completely prevent SE-induced vasogenic edema and neuronal damage in the PC.
T219 1235-1360 Sentence denotes In the present study, sTNFp55 infusion could not completely prevent SE-induced vasogenic edema and neuronal damage in the PC.
T11635 1361-1480 Sentence denotes Therefore, our findings suggest that TNF-α signaling may not be a unique upstream event in vasogenic edema development.
T220 1361-1480 Sentence denotes Therefore, our findings suggest that TNF-α signaling may not be a unique upstream event in vasogenic edema development.