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PMC:3312845 / 26911-28469 JSONTXT 22 Projects

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Id Subject Object Predicate Lexical cue
T10476 0-82 Sentence denotes MIP-2 is a powerful chemokine that contributes to recruitment of neutrophils [27].
T201 0-82 Sentence denotes MIP-2 is a powerful chemokine that contributes to recruitment of neutrophils [27].
T10477 83-288 Sentence denotes MIP-2 is undetectable or present at low levels under physiological conditions, and shows transient increases under pathological conditions via TNF-α and/or interleukin-1β (IL-1β)-dependent mechanisms [14].
T202 83-288 Sentence denotes MIP-2 is undetectable or present at low levels under physiological conditions, and shows transient increases under pathological conditions via TNF-α and/or interleukin-1β (IL-1β)-dependent mechanisms [14].
T10478 289-402 Sentence denotes Thus, it would be plausible that TNF-α-mediated MIP-2 expression may provoke SE-induced neutrophil infiltrations.
T203 289-402 Sentence denotes Thus, it would be plausible that TNF-α-mediated MIP-2 expression may provoke SE-induced neutrophil infiltrations.
T10479 403-474 Sentence denotes To confirm this hypothesis, we investigated MIP-2 expression in the PC.
T204 403-474 Sentence denotes To confirm this hypothesis, we investigated MIP-2 expression in the PC.
T10480 475-680 Sentence denotes Consistent with our previous study [20], some MIP-2-positive astrocytes were observed in the core and periphery of the vasogenic edema lesions, but not in the non-vasogenic edema region (Figure 6B and 6C).
T205 475-680 Sentence denotes Consistent with our previous study [20], some MIP-2-positive astrocytes were observed in the core and periphery of the vasogenic edema lesions, but not in the non-vasogenic edema region (Figure 6B and 6C).
T10481 681-1062 Sentence denotes Although the number of MIP-2 positive cells per unit area in the PC region of sTNFp55R-infused animals was significantly lower than that of the saline-infused group due to reduction of the area of vasogenic edema, there was no difference in the number of MIP-2 positive cells per unit area of vasogenic edema between sTNFp55R-infused animals and saline-infused animals (Figure 6F).
T206 681-1062 Sentence denotes Although the number of MIP-2 positive cells per unit area in the PC region of sTNFp55R-infused animals was significantly lower than that of the saline-infused group due to reduction of the area of vasogenic edema, there was no difference in the number of MIP-2 positive cells per unit area of vasogenic edema between sTNFp55R-infused animals and saline-infused animals (Figure 6F).
T10482 1063-1246 Sentence denotes Furthermore, the number of MIP-2-positive cells showed a direct proportion to the unit area of vasogenic edema with a linear coefficient of correlation of 0.682 (p < 0.05, Figure 6G).
T207 1063-1246 Sentence denotes Furthermore, the number of MIP-2-positive cells showed a direct proportion to the unit area of vasogenic edema with a linear coefficient of correlation of 0.682 (p < 0.05, Figure 6G).
T10483 1247-1558 Sentence denotes Therefore, together with reduction in neutrophil infiltration in the PC region of sTNFp55R-infused animals, our findings provide evidence that TNF-α may regulate SE-induced neutrophil infiltration at least in the PC via vasogenic edema formation and not via direct TNF-α-mediated MIP-2 expression in astrocytes.
T208 1247-1558 Sentence denotes Therefore, together with reduction in neutrophil infiltration in the PC region of sTNFp55R-infused animals, our findings provide evidence that TNF-α may regulate SE-induced neutrophil infiltration at least in the PC via vasogenic edema formation and not via direct TNF-α-mediated MIP-2 expression in astrocytes.