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PMC:3312845 / 235-1817 JSONTXT 23 Projects

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Id Subject Object Predicate Lexical cue
T103 0-10 Sentence denotes Background
T3 0-10 Sentence denotes Background
T104 11-141 Sentence denotes Status epilepticus (SE) induces severe vasogenic edema in the piriform cortex (PC) accompanied by neuronal and astroglial damages.
T4 11-141 Sentence denotes Status epilepticus (SE) induces severe vasogenic edema in the piriform cortex (PC) accompanied by neuronal and astroglial damages.
T105 142-403 Sentence denotes To elucidate the mechanism of SE-induced vasogenic edema, we investigated the roles of tumor necrosis factor (TNF)-α in blood-brain barrier (BBB) disruption during vasogenic edema and its related events in rat epilepsy models provoked by pilocarpine-induced SE.
T5 142-403 Sentence denotes To elucidate the mechanism of SE-induced vasogenic edema, we investigated the roles of tumor necrosis factor (TNF)-α in blood-brain barrier (BBB) disruption during vasogenic edema and its related events in rat epilepsy models provoked by pilocarpine-induced SE.
T106 405-412 Sentence denotes Methods
T6 405-412 Sentence denotes Methods
T107 413-571 Sentence denotes SE was induced by pilocarpine in rats that were intracerebroventricularly infused with saline-, and soluble TNF p55 receptor (sTNFp55R) prior to SE induction.
T7 413-571 Sentence denotes SE was induced by pilocarpine in rats that were intracerebroventricularly infused with saline-, and soluble TNF p55 receptor (sTNFp55R) prior to SE induction.
T108 572-681 Sentence denotes Thereafter, we performed Fluoro-Jade B staining and immunohistochemical studies for TNF-α and NF-κB subunits.
T8 572-681 Sentence denotes Thereafter, we performed Fluoro-Jade B staining and immunohistochemical studies for TNF-α and NF-κB subunits.
T109 683-690 Sentence denotes Results
T9 683-690 Sentence denotes Results
T110 691-767 Sentence denotes Following SE, most activated microglia showed strong TNF-α immunoreactivity.
T10 691-767 Sentence denotes Following SE, most activated microglia showed strong TNF-α immunoreactivity.
T111 768-865 Sentence denotes In addition, TNF p75 receptor expression was detected in endothelial cells as well as astrocytes.
T11 768-865 Sentence denotes In addition, TNF p75 receptor expression was detected in endothelial cells as well as astrocytes.
T112 866-1012 Sentence denotes In addition, only p65-Thr435 phosphorylation was increased in endothelial cells accompanied by SMI-71 expression (an endothelial barrier antigen).
T12 866-1012 Sentence denotes In addition, only p65-Thr435 phosphorylation was increased in endothelial cells accompanied by SMI-71 expression (an endothelial barrier antigen).
T113 1013-1210 Sentence denotes Neutralization of TNF-α by soluble TNF p55 receptor (sTNFp55R) infusion attenuated SE-induced vasogenic edema and neuronal damages via inhibition of p65-Thr435 phosphorylation in endothelial cells.
T13 1013-1210 Sentence denotes Neutralization of TNF-α by soluble TNF p55 receptor (sTNFp55R) infusion attenuated SE-induced vasogenic edema and neuronal damages via inhibition of p65-Thr435 phosphorylation in endothelial cells.
T114 1211-1295 Sentence denotes Furthermore, sTNFp55R infusion reduced SE-induced neutrophil infiltration in the PC.
T14 1211-1295 Sentence denotes Furthermore, sTNFp55R infusion reduced SE-induced neutrophil infiltration in the PC.
T115 1297-1307 Sentence denotes Conclusion
T15 1297-1307 Sentence denotes Conclusion
T116 1308-1477 Sentence denotes These findings suggest that impairments of endothelial cell functions via TNF-α-mediated p65-Thr 485 NF-κB phosphorylation may be involved in SE-induced vasogenic edema.
T16 1308-1477 Sentence denotes These findings suggest that impairments of endothelial cell functions via TNF-α-mediated p65-Thr 485 NF-κB phosphorylation may be involved in SE-induced vasogenic edema.
T117 1478-1582 Sentence denotes Subsequently, vasogenic edema results in extensive neutrophil infiltration and neuronal-astroglial loss.
T17 1478-1582 Sentence denotes Subsequently, vasogenic edema results in extensive neutrophil infiltration and neuronal-astroglial loss.