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T142 0-7 Sentence denotes Results
T7823 9-43 Sentence denotes TNF-α, and TNF receptor expression
T143 9-43 Sentence denotes TNF-α, and TNF receptor expression
T7824 44-174 Sentence denotes In non-SE induced animals of the saline-infused groups, TNF-α immunoreactivity was weakly detected in PC neurons (data not shown).
T144 44-174 Sentence denotes In non-SE induced animals of the saline-infused groups, TNF-α immunoreactivity was weakly detected in PC neurons (data not shown).
T7825 175-310 Sentence denotes In 12 hr-post SE animals of the saline-infused group, most of the activated microglia showed strong TNF-α immunoreactivity (Figure 1A).
T145 175-310 Sentence denotes In 12 hr-post SE animals of the saline-infused group, most of the activated microglia showed strong TNF-α immunoreactivity (Figure 1A).
T7826 311-372 Sentence denotes This expression pattern was maintained up to 1 week after SE.
T146 311-372 Sentence denotes This expression pattern was maintained up to 1 week after SE.
T7827 373-525 Sentence denotes In non-SE-induced animals of the saline-infused groups, TNFp55R and TNFp75R immunoreactivities were also weakly observed in astrocytes (data not shown).
T147 373-525 Sentence denotes In non-SE-induced animals of the saline-infused groups, TNFp55R and TNFp75R immunoreactivities were also weakly observed in astrocytes (data not shown).
T7828 526-644 Sentence denotes In 12 hr-post SE animals of the saline-infused group, TNFp55R immunoreactivity was observed in astrocytes (Figure 1B).
T148 526-644 Sentence denotes In 12 hr-post SE animals of the saline-infused group, TNFp55R immunoreactivity was observed in astrocytes (Figure 1B).
T7829 645-757 Sentence denotes Unlike TNFp55R, TNFp75R immunoreactivity was detected in endothelial cells as well as astrocytes (Figures 1C-E).
T149 645-757 Sentence denotes Unlike TNFp55R, TNFp75R immunoreactivity was detected in endothelial cells as well as astrocytes (Figures 1C-E).
T7830 758-957 Sentence denotes One day to 1 week after SE, both TNFp55R and TNFp75R immunoreactivities were significantly reduced in astrocytes, not in endothelial cells, due to massive astroglial loss (data not shown) [5,7,8,20].
T150 758-957 Sentence denotes One day to 1 week after SE, both TNFp55R and TNFp75R immunoreactivities were significantly reduced in astrocytes, not in endothelial cells, due to massive astroglial loss (data not shown) [5,7,8,20].
T151 958-1219 Sentence denotes Figure 1 Expression of TNF-α and TNF receptor in the PC 12 hr-post SE. (A) TNF-α immunoreactivity in Ox-42-positive microglia (arrows). (B) TNFp55R expression in astrocytes (arrows). (C-D) TNFp75R expression in astrocytes as well as endothelial cells (arrows).
T14488 968-1219 Sentence denotes Expression of TNF-α and TNF receptor in the PC 12 hr-post SE. (A) TNF-α immunoreactivity in Ox-42-positive microglia (arrows). (B) TNFp55R expression in astrocytes (arrows). (C-D) TNFp75R expression in astrocytes as well as endothelial cells (arrows).
T14489 1220-1238 Sentence denotes Bar = 25 (A-D) μm.
T152 1220-1238 Sentence denotes Bar = 25 (A-D) μm.
T8344 1240-1329 Sentence denotes Effect of sTNFp55R infusion on SE-induced serum-protein extravasation and neuronal damage
T153 1240-1329 Sentence denotes Effect of sTNFp55R infusion on SE-induced serum-protein extravasation and neuronal damage
T8345 1330-1474 Sentence denotes In our previous [5,7,8,20] and preliminary data, vasogenic edema and neuronal damage were noticeable at 1 day and 3 days after SE, respectively.
T154 1330-1474 Sentence denotes In our previous [5,7,8,20] and preliminary data, vasogenic edema and neuronal damage were noticeable at 1 day and 3 days after SE, respectively.
T8346 1475-1648 Sentence denotes Therefore, we determined that 3 days after SE was the best time point to evaluate the effect of sTNFp55R infusion on both vasogenic edema and neuronal damages induced by SE.
T155 1475-1648 Sentence denotes Therefore, we determined that 3 days after SE was the best time point to evaluate the effect of sTNFp55R infusion on both vasogenic edema and neuronal damages induced by SE.
T8347 1649-1735 Sentence denotes In saline-treated animals, the PC was stained diffusely with anti-rat IgG (Figure 2A).
T156 1649-1735 Sentence denotes In saline-treated animals, the PC was stained diffusely with anti-rat IgG (Figure 2A).
T8348 1736-1797 Sentence denotes The volume of vasogenic edema was 17.1 ± 1.5 mm3 (Figure 2E).
T157 1736-1797 Sentence denotes The volume of vasogenic edema was 17.1 ± 1.5 mm3 (Figure 2E).
T8349 1798-1876 Sentence denotes The number of FJB-positive neurons in the PC was 236,145 ± 49,469 (Figure 2B).
T158 1798-1876 Sentence denotes The number of FJB-positive neurons in the PC was 236,145 ± 49,469 (Figure 2B).
T8350 1877-1985 Sentence denotes In sTNFp55R-treated animals, SE-induced vasogenic edema was attenuated to 9.8 ± 0.7 mm3 (Figures 2C and 2E).
T159 1877-1985 Sentence denotes In sTNFp55R-treated animals, SE-induced vasogenic edema was attenuated to 9.8 ± 0.7 mm3 (Figures 2C and 2E).
T8351 1986-2078 Sentence denotes In addition, the number of FJB-positive neurons in the PC was 89,138 ± 5,698 (Figures 2D-E).
T160 1986-2078 Sentence denotes In addition, the number of FJB-positive neurons in the PC was 89,138 ± 5,698 (Figures 2D-E).
T8352 2079-2207 Sentence denotes Thus, sTNFp55R infusion attenuated SE-induced vasogenic edema and neuronal damage compared to saline-infused animals (p < 0.05).
T161 2079-2207 Sentence denotes Thus, sTNFp55R infusion attenuated SE-induced vasogenic edema and neuronal damage compared to saline-infused animals (p < 0.05).
T162 2208-2403 Sentence denotes Figure 2 Effect of sTNFp55R infusion on SE-induced serum-protein extravasation and neuronal damage. (A-D) Serum-protein extravasation and FJB-positive neuronal damages in the PC 3 days after SE.
T14706 2218-2403 Sentence denotes Effect of sTNFp55R infusion on SE-induced serum-protein extravasation and neuronal damage. (A-D) Serum-protein extravasation and FJB-positive neuronal damages in the PC 3 days after SE.
T14707 2404-2553 Sentence denotes Compared to saline-infused animals, serum-protein extravasation and FJB-positive neuronal damage is markedly ameliorated in sTNFp55R-infused animals.
T163 2404-2553 Sentence denotes Compared to saline-infused animals, serum-protein extravasation and FJB-positive neuronal damage is markedly ameliorated in sTNFp55R-infused animals.
T14708 2554-2727 Sentence denotes Bars = 400 (A and C) and 50 (B and D) μm. (E) Quantitative analyses of serum-protein extravasation and FJB-positive neuronal damage in the PC 3 days after SE (mean ± S.E.M).
T164 2554-2727 Sentence denotes Bars = 400 (A and C) and 50 (B and D) μm. (E) Quantitative analyses of serum-protein extravasation and FJB-positive neuronal damage in the PC 3 days after SE (mean ± S.E.M).
T14709 2728-2791 Sentence denotes Significant differences from saline-treated animals, *p < 0.05.
T165 2728-2791 Sentence denotes Significant differences from saline-treated animals, *p < 0.05.
T8685 2793-2814 Sentence denotes NF-κB phosphorylation
T166 2793-2814 Sentence denotes NF-κB phosphorylation
T8686 2815-2909 Sentence denotes It is well established that TNF-α is one of the major stimuli toward phosphorylation of NF-κB.
T167 2815-2909 Sentence denotes It is well established that TNF-α is one of the major stimuli toward phosphorylation of NF-κB.
T8687 2910-3038 Sentence denotes To confirm TNF-α-mediated signaling following SE, we performed an immunohistochemical study using five phospho-NF-κB antibodies.
T168 2910-3038 Sentence denotes To confirm TNF-α-mediated signaling following SE, we performed an immunohistochemical study using five phospho-NF-κB antibodies.
T8688 3039-3439 Sentence denotes Compared to non-SE animals (data not shown), 12 hr-post SE animals of the saline-infused group showed p65-Ser276, p65-Ser311, p65-Ser529, and p65-Ser536 phosphorylation in astrocytes (not endothelial cells). sTNFp55R infusion effectively reduced p65-Ser276 and p65-Ser311 phosphorylation (p < 0.05, respectively), while it could not affect p65-Ser529 or p65-Ser536 phosphorylation (Figures 3 and 4A).
T169 3039-3439 Sentence denotes Compared to non-SE animals (data not shown), 12 hr-post SE animals of the saline-infused group showed p65-Ser276, p65-Ser311, p65-Ser529, and p65-Ser536 phosphorylation in astrocytes (not endothelial cells). sTNFp55R infusion effectively reduced p65-Ser276 and p65-Ser311 phosphorylation (p < 0.05, respectively), while it could not affect p65-Ser529 or p65-Ser536 phosphorylation (Figures 3 and 4A).
T8689 3440-3599 Sentence denotes In contrast, p65-Thr435 phosphorylation was increased in endothelial cells (not astrocytes) within the PC of saline-infused animals 12 hr after SE (Figure 5A).
T170 3440-3599 Sentence denotes In contrast, p65-Thr435 phosphorylation was increased in endothelial cells (not astrocytes) within the PC of saline-infused animals 12 hr after SE (Figure 5A).
T8690 3600-3764 Sentence denotes In addition, sTNFp55R infusion effectively alleviated SE-induced p65-Thr435 phosphorylation in endothelial cells, compared to saline infusion (p < 0.05, Figure 5B).
T171 3600-3764 Sentence denotes In addition, sTNFp55R infusion effectively alleviated SE-induced p65-Thr435 phosphorylation in endothelial cells, compared to saline infusion (p < 0.05, Figure 5B).
T172 3765-3857 Sentence denotes Figure 3 Effect of sTNFp55R infusion on NF-κB phosphorylation in astrocytes 12 hr after SE.
T15005 3775-3857 Sentence denotes Effect of sTNFp55R infusion on NF-κB phosphorylation in astrocytes 12 hr after SE.
T15006 3858-4226 Sentence denotes In 12 hr-post SE animals of the saline-infused group (A, C, E and G), astrocytes show p65-Ser276 (A), p65-Ser311 (C), p65-Ser529 (E), and p65-Ser536 (G) phosphorylation (arrows). sTNFp55R infusion (B, D, F and H) effectively reduces p65-Ser276 (B) and p65-Ser311 (D) phosphorylation, while it does not affect p65-Ser529 (F) and p65-Ser536 (H) phosphorylation (arrows).
T173 3858-4226 Sentence denotes In 12 hr-post SE animals of the saline-infused group (A, C, E and G), astrocytes show p65-Ser276 (A), p65-Ser311 (C), p65-Ser529 (E), and p65-Ser536 (G) phosphorylation (arrows). sTNFp55R infusion (B, D, F and H) effectively reduces p65-Ser276 (B) and p65-Ser311 (D) phosphorylation, while it does not affect p65-Ser529 (F) and p65-Ser536 (H) phosphorylation (arrows).
T15007 4227-4241 Sentence denotes Bar = 12.5 μm.
T174 4227-4241 Sentence denotes Bar = 12.5 μm.
T175 4242-4438 Sentence denotes Figure 4 Quantitative analyses of the effect of sTNFp55R infusion on NF-κB phosphorylation and SMI-71 expression. (A) Quantitative analysis of NF-κB phosphorylation 12 hr after SE (mean ± S.E.M).
T15460 4252-4438 Sentence denotes Quantitative analyses of the effect of sTNFp55R infusion on NF-κB phosphorylation and SMI-71 expression. (A) Quantitative analysis of NF-κB phosphorylation 12 hr after SE (mean ± S.E.M).
T15461 4439-4580 Sentence denotes Significant differences from saline-infused animals, *p < 0.05. (B) Quantitative analysis of SMI-71 expression 1 day after SE (mean ± S.E.M).
T176 4439-4580 Sentence denotes Significant differences from saline-infused animals, *p < 0.05. (B) Quantitative analysis of SMI-71 expression 1 day after SE (mean ± S.E.M).
T15462 4581-4745 Sentence denotes Significant differences from saline-infused animals, *p < 0.05. (C) Linear regression analysis between p65-Thr435 phosphorylation and SMI-71 in the PC following SE.
T177 4581-4745 Sentence denotes Significant differences from saline-infused animals, *p < 0.05. (C) Linear regression analysis between p65-Thr435 phosphorylation and SMI-71 in the PC following SE.
T178 4746-5489 Sentence denotes Figure 5 Effect of sTNFp55R infusion on p65-Thr435 phosphorylation in endothelial cells following SE. (A-B) Inhibition of p65-Thr435 phosphorylation by sTNFp55R infusion 12 hr after SE. p65-Thr435 phosphorylation is rarely observed in astrocytes (arrows). (C) Endothelial p65-Thr435 phosphorylation in non-SE animals. (D-E) Endothelial p65-Thr435 phosphorylation in saline-infused animals 1 day after SE. p65-Thr435 phosphorylation is enhanced, while SMI-71 expression is reduced in GLUT-1-positive endothelial cells (arrows). (F-G) Endothelial p65-Thr435 phosphorylation in sTNFp55R-infused animal 1 day after SE. sTNFp55R infusion effectively reduces p65-Thr435 and preserves SMI-71 expression in GLUT-1-positive endothelial cells (arrows).
T15783 4756-5489 Sentence denotes Effect of sTNFp55R infusion on p65-Thr435 phosphorylation in endothelial cells following SE. (A-B) Inhibition of p65-Thr435 phosphorylation by sTNFp55R infusion 12 hr after SE. p65-Thr435 phosphorylation is rarely observed in astrocytes (arrows). (C) Endothelial p65-Thr435 phosphorylation in non-SE animals. (D-E) Endothelial p65-Thr435 phosphorylation in saline-infused animals 1 day after SE. p65-Thr435 phosphorylation is enhanced, while SMI-71 expression is reduced in GLUT-1-positive endothelial cells (arrows). (F-G) Endothelial p65-Thr435 phosphorylation in sTNFp55R-infused animal 1 day after SE. sTNFp55R infusion effectively reduces p65-Thr435 and preserves SMI-71 expression in GLUT-1-positive endothelial cells (arrows).
T15784 5490-5524 Sentence denotes Bars = 12.5 (A-D) and 25 (E-G) μm.
T179 5490-5524 Sentence denotes Bars = 12.5 (A-D) and 25 (E-G) μm.
T9403 5526-5543 Sentence denotes SMI-71 expression
T180 5526-5543 Sentence denotes SMI-71 expression
T9404 5544-5669 Sentence denotes Previously, we reported that SMI-71 (an endothelial barrier antigen) immunoreactivity decreased in the PC 1 day after SE [5].
T181 5544-5669 Sentence denotes Previously, we reported that SMI-71 (an endothelial barrier antigen) immunoreactivity decreased in the PC 1 day after SE [5].
T9405 5670-5868 Sentence denotes Similarly, in 1 day-post SE animals of the saline-infused group, loss of SMI-71 immunoreactivity was detected in layer III/IV of the PC as compared to non-SE animals (Figures 4B and 5C-E, p < 0.05).
T182 5670-5868 Sentence denotes Similarly, in 1 day-post SE animals of the saline-infused group, loss of SMI-71 immunoreactivity was detected in layer III/IV of the PC as compared to non-SE animals (Figures 4B and 5C-E, p < 0.05).
T9406 5869-5962 Sentence denotes Thus, loss of SMI-71 immunoreactivity correlated with volume of vasogenic edema following SE.
T183 5869-5962 Sentence denotes Thus, loss of SMI-71 immunoreactivity correlated with volume of vasogenic edema following SE.
T9407 5963-6059 Sentence denotes This reduction in SMI-71 was accompanied by increased p65-Thr435 phosphorylation (Figures 5C-D).
T184 5963-6059 Sentence denotes This reduction in SMI-71 was accompanied by increased p65-Thr435 phosphorylation (Figures 5C-D).
T9408 6060-6238 Sentence denotes Therefore, the degree of SMI-71 immunoreactivity was inversely correlated to p65-Thr435 phosphorylation with a linear coefficient of correlation of -0.6324 (p < 0.05; Figure 4C).
T185 6060-6238 Sentence denotes Therefore, the degree of SMI-71 immunoreactivity was inversely correlated to p65-Thr435 phosphorylation with a linear coefficient of correlation of -0.6324 (p < 0.05; Figure 4C).
T9409 6239-6460 Sentence denotes In addition, sTNFp55R infusion effectively alleviated p65-Thr435 phosphorylation and preserved SMI-71 immunoreactivity in endothelial cells following SE, as compared to saline infusion (p < 0.05; Figures 4A-B, 5D and 5F).
T186 6239-6460 Sentence denotes In addition, sTNFp55R infusion effectively alleviated p65-Thr435 phosphorylation and preserved SMI-71 immunoreactivity in endothelial cells following SE, as compared to saline infusion (p < 0.05; Figures 4A-B, 5D and 5F).
T9880 6462-6485 Sentence denotes Neutrophil infiltration
T187 6462-6485 Sentence denotes Neutrophil infiltration
T9881 6486-6596 Sentence denotes Recent studies have reported that neutrophils infiltrate the brain under certain pathological conditions [26].
T188 6486-6596 Sentence denotes Recent studies have reported that neutrophils infiltrate the brain under certain pathological conditions [26].
T9882 6597-6700 Sentence denotes Indeed, we have reported massive neutrophil infiltration in layer III/IV of the PC 1 day after SE [20].
T189 6597-6700 Sentence denotes Indeed, we have reported massive neutrophil infiltration in layer III/IV of the PC 1 day after SE [20].
T9883 6701-6833 Sentence denotes In the present study, 1 day-post-SE animals of the saline-infused group showed infiltration of MPO-positive neutrophils into the PC.
T190 6701-6833 Sentence denotes In the present study, 1 day-post-SE animals of the saline-infused group showed infiltration of MPO-positive neutrophils into the PC.
T9884 6834-6967 Sentence denotes Similarly, 1 day-post-SE animals of the sTNFp55R-infused group showed neutrophil infiltration into the PC 1 day after SE (Figure 6A).
T191 6834-6967 Sentence denotes Similarly, 1 day-post-SE animals of the sTNFp55R-infused group showed neutrophil infiltration into the PC 1 day after SE (Figure 6A).
T9885 6968-7202 Sentence denotes The number of neutrophils/area in the PC region (including the vasogenic edema region and the non-vasogenic edema region) of sTNFp55R-infused animals was significantly lower than that of the saline-infused group (Figure 6D, p < 0.05).
T192 6968-7202 Sentence denotes The number of neutrophils/area in the PC region (including the vasogenic edema region and the non-vasogenic edema region) of sTNFp55R-infused animals was significantly lower than that of the saline-infused group (Figure 6D, p < 0.05).
T9886 7203-7356 Sentence denotes However, there was no difference in neutrophil infiltration per unit area of vasogenic edema between the saline- and sTNFp55R-infused groups (Figure 6D).
T193 7203-7356 Sentence denotes However, there was no difference in neutrophil infiltration per unit area of vasogenic edema between the saline- and sTNFp55R-infused groups (Figure 6D).
T9887 7357-7526 Sentence denotes Furthermore, neutrophil infiltration showed a direct proportion to the area of vasogenic edema, with a linear coefficient of correlation of 0.8631 (p < 0.05, Figure 6E).
T194 7357-7526 Sentence denotes Furthermore, neutrophil infiltration showed a direct proportion to the area of vasogenic edema, with a linear coefficient of correlation of 0.8631 (p < 0.05, Figure 6E).
T9888 7527-7674 Sentence denotes Therefore, our findings indicate that SE-induced neutrophil infiltration into the PC may be correlated to TNF-α-mediated vasogenic edema formation.
T195 7527-7674 Sentence denotes Therefore, our findings indicate that SE-induced neutrophil infiltration into the PC may be correlated to TNF-α-mediated vasogenic edema formation.
T196 7675-7936 Sentence denotes Figure 6 Effect of sTNFp55R infusion on neutrophil infiltration and MIP-2 expression following SE. (A) Neutrophil infiltration in vasogenic edema lesion 1 day after SE. (B) MIP-2 expression in the PC 1 day after SE. (C) Astroglial expression of MIP-2 (arrows).
T16281 7685-7936 Sentence denotes Effect of sTNFp55R infusion on neutrophil infiltration and MIP-2 expression following SE. (A) Neutrophil infiltration in vasogenic edema lesion 1 day after SE. (B) MIP-2 expression in the PC 1 day after SE. (C) Astroglial expression of MIP-2 (arrows).
T16282 7937-8058 Sentence denotes Bars = 12.5 (A and C) and 150 (B) μm. (D) Quantitative analysis of neutrophil infiltration 1 day after SE (mean ± S.E.M).
T197 7937-8058 Sentence denotes Bars = 12.5 (A and C) and 150 (B) μm. (D) Quantitative analysis of neutrophil infiltration 1 day after SE (mean ± S.E.M).
T16283 8059-8409 Sentence denotes Significant differences from saline-infused animals, *p < 0.05. (E) Linear regression analysis between the number of infiltrated neutrophils/area in the vasogenic edema region and the area of vasogenic edema in the PC. (F) Quantitative analysis of the number of MIP-2 positive cells per the unit area of vasogenic edema 1 day after SE (mean ± S.E.M).
T198 8059-8409 Sentence denotes Significant differences from saline-infused animals, *p < 0.05. (E) Linear regression analysis between the number of infiltrated neutrophils/area in the vasogenic edema region and the area of vasogenic edema in the PC. (F) Quantitative analysis of the number of MIP-2 positive cells per the unit area of vasogenic edema 1 day after SE (mean ± S.E.M).
T16284 8410-8721 Sentence denotes There is no difference in the number of MIP-2-positive cells per unit area of vasogenic edema between sTNFp55R-infused animals and saline-infused animals. (G) Linear regression analysis between the number of MIP-2 positive cells per unit area in vasogenic edema region and the area of vasogenic edema in the PC.
T199 8410-8721 Sentence denotes There is no difference in the number of MIP-2-positive cells per unit area of vasogenic edema between sTNFp55R-infused animals and saline-infused animals. (G) Linear regression analysis between the number of MIP-2 positive cells per unit area in vasogenic edema region and the area of vasogenic edema in the PC.
T10475 8723-8739 Sentence denotes MIP-2 expression
T200 8723-8739 Sentence denotes MIP-2 expression
T10476 8740-8822 Sentence denotes MIP-2 is a powerful chemokine that contributes to recruitment of neutrophils [27].
T201 8740-8822 Sentence denotes MIP-2 is a powerful chemokine that contributes to recruitment of neutrophils [27].
T10477 8823-9028 Sentence denotes MIP-2 is undetectable or present at low levels under physiological conditions, and shows transient increases under pathological conditions via TNF-α and/or interleukin-1β (IL-1β)-dependent mechanisms [14].
T202 8823-9028 Sentence denotes MIP-2 is undetectable or present at low levels under physiological conditions, and shows transient increases under pathological conditions via TNF-α and/or interleukin-1β (IL-1β)-dependent mechanisms [14].
T10478 9029-9142 Sentence denotes Thus, it would be plausible that TNF-α-mediated MIP-2 expression may provoke SE-induced neutrophil infiltrations.
T203 9029-9142 Sentence denotes Thus, it would be plausible that TNF-α-mediated MIP-2 expression may provoke SE-induced neutrophil infiltrations.
T10479 9143-9214 Sentence denotes To confirm this hypothesis, we investigated MIP-2 expression in the PC.
T204 9143-9214 Sentence denotes To confirm this hypothesis, we investigated MIP-2 expression in the PC.
T10480 9215-9420 Sentence denotes Consistent with our previous study [20], some MIP-2-positive astrocytes were observed in the core and periphery of the vasogenic edema lesions, but not in the non-vasogenic edema region (Figure 6B and 6C).
T205 9215-9420 Sentence denotes Consistent with our previous study [20], some MIP-2-positive astrocytes were observed in the core and periphery of the vasogenic edema lesions, but not in the non-vasogenic edema region (Figure 6B and 6C).
T10481 9421-9802 Sentence denotes Although the number of MIP-2 positive cells per unit area in the PC region of sTNFp55R-infused animals was significantly lower than that of the saline-infused group due to reduction of the area of vasogenic edema, there was no difference in the number of MIP-2 positive cells per unit area of vasogenic edema between sTNFp55R-infused animals and saline-infused animals (Figure 6F).
T206 9421-9802 Sentence denotes Although the number of MIP-2 positive cells per unit area in the PC region of sTNFp55R-infused animals was significantly lower than that of the saline-infused group due to reduction of the area of vasogenic edema, there was no difference in the number of MIP-2 positive cells per unit area of vasogenic edema between sTNFp55R-infused animals and saline-infused animals (Figure 6F).
T10482 9803-9986 Sentence denotes Furthermore, the number of MIP-2-positive cells showed a direct proportion to the unit area of vasogenic edema with a linear coefficient of correlation of 0.682 (p < 0.05, Figure 6G).
T207 9803-9986 Sentence denotes Furthermore, the number of MIP-2-positive cells showed a direct proportion to the unit area of vasogenic edema with a linear coefficient of correlation of 0.682 (p < 0.05, Figure 6G).
T10483 9987-10298 Sentence denotes Therefore, together with reduction in neutrophil infiltration in the PC region of sTNFp55R-infused animals, our findings provide evidence that TNF-α may regulate SE-induced neutrophil infiltration at least in the PC via vasogenic edema formation and not via direct TNF-α-mediated MIP-2 expression in astrocytes.
T208 9987-10298 Sentence denotes Therefore, together with reduction in neutrophil infiltration in the PC region of sTNFp55R-infused animals, our findings provide evidence that TNF-α may regulate SE-induced neutrophil infiltration at least in the PC via vasogenic edema formation and not via direct TNF-α-mediated MIP-2 expression in astrocytes.