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PMC:3279418 / 1758-4724 JSONTXT 18 Projects

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Id Subject Object Predicate Lexical cue
T13 0-12 Sentence denotes Introduction
T978 13-188 Sentence denotes SHARPIN was originally identified in post-synaptic densities of excitatory synapses in the brain of rats [1], but this protein is widely expressed in a variety of tissues [2].
T14 13-188 Sentence denotes SHARPIN was originally identified in post-synaptic densities of excitatory synapses in the brain of rats [1], but this protein is widely expressed in a variety of tissues [2].
T979 189-495 Sentence denotes Two allelic, autosomal recessive mutations in the Sharpin gene occurred spontaneously in two inbred strains of mice, C57B/KaLawRij-Sharpincpdm/Sharpincpdm and CBy.Ocb3/Dem-Sharpincpdm-Dem/Sharpincpdm-Dem, resulting in premature termination of mRNA synthesis and absence of a functional protein product [2].
T15 189-495 Sentence denotes Two allelic, autosomal recessive mutations in the Sharpin gene occurred spontaneously in two inbred strains of mice, C57B/KaLawRij-Sharpincpdm/Sharpincpdm and CBy.Ocb3/Dem-Sharpincpdm-Dem/Sharpincpdm-Dem, resulting in premature termination of mRNA synthesis and absence of a functional protein product [2].
T980 496-691 Sentence denotes Despite different genetic backgrounds, both mutations cause similar inflammatory disease with severe chronic progressive dermatitis and defective development of secondary lymphoid organs [2]–[4].
T16 496-691 Sentence denotes Despite different genetic backgrounds, both mutations cause similar inflammatory disease with severe chronic progressive dermatitis and defective development of secondary lymphoid organs [2]–[4].
T981 692-762 Sentence denotes The dermatitis becomes clinically apparent at about four weeks of age.
T17 692-762 Sentence denotes The dermatitis becomes clinically apparent at about four weeks of age.
T982 763-1038 Sentence denotes There are accumulations of eosinophils, neutrophils and macrophages in the skin of Sharpincpdm/Sharpincpdm mutant mice (hereafter referred to as cpdm mice) associated with increased expression of Th2 cytokines in the skin and in the supernatants of activated splenocytes [5].
T18 763-1038 Sentence denotes There are accumulations of eosinophils, neutrophils and macrophages in the skin of Sharpincpdm/Sharpincpdm mutant mice (hereafter referred to as cpdm mice) associated with increased expression of Th2 cytokines in the skin and in the supernatants of activated splenocytes [5].
T983 1039-1226 Sentence denotes The mice have an impaired delayed type hypersensitivity response and decreased secretion of IFNγ [5], indicating a defect in Th1 immune responses and a bias towards a Th2 immune response.
T19 1039-1226 Sentence denotes The mice have an impaired delayed type hypersensitivity response and decreased secretion of IFNγ [5], indicating a defect in Th1 immune responses and a bias towards a Th2 immune response.
T984 1227-1329 Sentence denotes Systemic treatment of cpdm mice with recombinant IL12 caused complete remission of the dermatitis [5].
T20 1227-1329 Sentence denotes Systemic treatment of cpdm mice with recombinant IL12 caused complete remission of the dermatitis [5].
T985 1330-1536 Sentence denotes Neutralization of IL5 by antibody treatment or crosses with IL5-deficient mice reduced the number of circulating and cutaneous eosinophils, but failed to reduce the onset and severity of the dermatitis [6].
T21 1330-1536 Sentence denotes Neutralization of IL5 by antibody treatment or crosses with IL5-deficient mice reduced the number of circulating and cutaneous eosinophils, but failed to reduce the onset and severity of the dermatitis [6].
T986 1537-1734 Sentence denotes Recently, three independent groups identified SHARPIN as an essential component of the linear ubiquitin chain assembly complex (LUBAC) that regulates TNFα-induced canonical NF-κB signaling [7]–[9].
T22 1537-1734 Sentence denotes Recently, three independent groups identified SHARPIN as an essential component of the linear ubiquitin chain assembly complex (LUBAC) that regulates TNFα-induced canonical NF-κB signaling [7]–[9].
T987 1735-1909 Sentence denotes SHARPIN-deficient mouse embryonic fibroblast (MEF) were sensitized to TNFα-induced apoptosis and cell death was implicated as a factor in the dermatitis of cpdm mice [7]–[9].
T23 1735-1909 Sentence denotes SHARPIN-deficient mouse embryonic fibroblast (MEF) were sensitized to TNFα-induced apoptosis and cell death was implicated as a factor in the dermatitis of cpdm mice [7]–[9].
T988 1910-2062 Sentence denotes Dendritic cells (DC) have a sentinel role in sensing pathogen or danger signals and initiate and direct activation of the adaptive immune response [10].
T24 1910-2062 Sentence denotes Dendritic cells (DC) have a sentinel role in sensing pathogen or danger signals and initiate and direct activation of the adaptive immune response [10].
T989 2063-2212 Sentence denotes Activated and mature DC can carry processed antigenic peptides, migrate to lymphoid organs, and induce T-cell-mediated immune responses or tolerance.
T25 2063-2212 Sentence denotes Activated and mature DC can carry processed antigenic peptides, migrate to lymphoid organs, and induce T-cell-mediated immune responses or tolerance.
T990 2213-2344 Sentence denotes DC direct the differentiation of CD4+ T cells, and hence the type of immune response, through the selective secretion of cytokines.
T26 2213-2344 Sentence denotes DC direct the differentiation of CD4+ T cells, and hence the type of immune response, through the selective secretion of cytokines.
T991 2345-2480 Sentence denotes We hypothesized that defective cytokine secretion by DC contributed to the Th2-biased inflammatory phenotype in SHARPIN-deficient mice.
T27 2345-2480 Sentence denotes We hypothesized that defective cytokine secretion by DC contributed to the Th2-biased inflammatory phenotype in SHARPIN-deficient mice.
T992 2481-2662 Sentence denotes The studies reported here found that lack of SHARPIN protein in BMDC caused defective expression of pro-inflammatory mediators and impaired NF-κB activation upon ligand stimulation.
T28 2481-2662 Sentence denotes The studies reported here found that lack of SHARPIN protein in BMDC caused defective expression of pro-inflammatory mediators and impaired NF-κB activation upon ligand stimulation.
T993 2663-2768 Sentence denotes The ability of cpdm BMDC to stimulate Th1 cytokine production in allogeneic CD4+ T cells was compromised.
T29 2663-2768 Sentence denotes The ability of cpdm BMDC to stimulate Th1 cytokine production in allogeneic CD4+ T cells was compromised.
T994 2769-2966 Sentence denotes Taken together, these results reveal that SHARPIN is a novel regulatory molecule in DC biology and suggest that the dysregulated function of SHARPIN-deficient DC plays a role in the cpdm phenotype.
T30 2769-2966 Sentence denotes Taken together, these results reveal that SHARPIN is a novel regulatory molecule in DC biology and suggest that the dysregulated function of SHARPIN-deficient DC plays a role in the cpdm phenotype.