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PMC:3279418 / 165-1757 JSONTXT 16 Projects

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Id Subject Object Predicate Lexical cue
T108 0-100 Sentence denotes Spontaneous mutations of the Sharpin (SHANK-associated RH domain-interacting protein, other aliases:
T3 0-100 Sentence denotes Spontaneous mutations of the Sharpin (SHANK-associated RH domain-interacting protein, other aliases:
T109 101-283 Sentence denotes Rbckl1, Sipl1) gene in mice result in systemic inflammation that is characterized by chronic proliferative dermatitis and dysregulated secretion of T helper1 (Th1) and Th2 cytokines.
T4 101-283 Sentence denotes Rbckl1, Sipl1) gene in mice result in systemic inflammation that is characterized by chronic proliferative dermatitis and dysregulated secretion of T helper1 (Th1) and Th2 cytokines.
T110 284-376 Sentence denotes The cellular and molecular mechanisms underlying this inflammatory phenotype remain elusive.
T5 284-376 Sentence denotes The cellular and molecular mechanisms underlying this inflammatory phenotype remain elusive.
T111 377-547 Sentence denotes Dendritic cells may contribute to the initiation and progression of the phenotype of SHARPIN-deficient mice because of their pivotal role in innate and adaptive immunity.
T6 377-547 Sentence denotes Dendritic cells may contribute to the initiation and progression of the phenotype of SHARPIN-deficient mice because of their pivotal role in innate and adaptive immunity.
T112 548-674 Sentence denotes Here we show by flow cytometry that SHARPIN- deficiency did not alter the distribution of different DC subtypes in the spleen.
T7 548-674 Sentence denotes Here we show by flow cytometry that SHARPIN- deficiency did not alter the distribution of different DC subtypes in the spleen.
T113 675-909 Sentence denotes In response to TOLL-like receptor (TLR) agonists LPS and poly I:C, cultured bone marrow-derived dendritic cells (BMDC) from WT and mutant mice exhibited similar increases in expression of co-stimulatory molecules CD40, CD80, and CD86.
T8 675-909 Sentence denotes In response to TOLL-like receptor (TLR) agonists LPS and poly I:C, cultured bone marrow-derived dendritic cells (BMDC) from WT and mutant mice exhibited similar increases in expression of co-stimulatory molecules CD40, CD80, and CD86.
T114 910-1061 Sentence denotes However, stimulated SHARPIN-deficient BMDC had reduced transcription and secretion of pro-inflammatory mediators IL6, IL12P70, GMCSF, and nitric oxide.
T9 910-1061 Sentence denotes However, stimulated SHARPIN-deficient BMDC had reduced transcription and secretion of pro-inflammatory mediators IL6, IL12P70, GMCSF, and nitric oxide.
T115 1062-1234 Sentence denotes Mutant BMDC had defective activation of NF-κB signaling, whereas the MAPK1/3 (ERK1/2) and MAPK11/12/13/14 (p38 MAP kinase isoforms) and TBK1 signaling pathways were intact.
T10 1062-1234 Sentence denotes Mutant BMDC had defective activation of NF-κB signaling, whereas the MAPK1/3 (ERK1/2) and MAPK11/12/13/14 (p38 MAP kinase isoforms) and TBK1 signaling pathways were intact.
T116 1235-1411 Sentence denotes A mixed lymphocyte reaction showed that mutant BMDC only induced a weak Th1 immune response but stimulated increased Th2 cytokine production from allogeneic naïve CD4+ T cells.
T11 1235-1411 Sentence denotes A mixed lymphocyte reaction showed that mutant BMDC only induced a weak Th1 immune response but stimulated increased Th2 cytokine production from allogeneic naïve CD4+ T cells.
T117 1412-1591 Sentence denotes In conclusion, loss of Sharpin in mice significantly affects the immune function of DC and this may partially account for the systemic inflammation and Th2-biased immune response.
T12 1412-1591 Sentence denotes In conclusion, loss of Sharpin in mice significantly affects the immune function of DC and this may partially account for the systemic inflammation and Th2-biased immune response.