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PMC:3218875 / 24005-25236 JSONTXT 24 Projects

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Id Subject Object Predicate Lexical cue
T12649 0-327 Sentence denotes Using oligonucleotide microarray analysis, ABIN-1 was identified among TNF-induced genes in human synoviocytes, and high levels of ABIN-1 mRNA were detected in RA tissue biopsies, indicating a potential role for ABIN-1, together with A20, in the negative feedback regulation of NF-κB signalling and the pathogenesis of RA [59].
T133 0-327 Sentence denotes Using oligonucleotide microarray analysis, ABIN-1 was identified among TNF-induced genes in human synoviocytes, and high levels of ABIN-1 mRNA were detected in RA tissue biopsies, indicating a potential role for ABIN-1, together with A20, in the negative feedback regulation of NF-κB signalling and the pathogenesis of RA [59].
T12650 328-536 Sentence denotes In a recent study, inhibition of TLR responses by immunoreceptor tyrosine-based activation motif (ITAM)-coupled receptors was shown to depend on the expression of the NF-κB inhibitory proteins ABIN-3 and A20.
T134 328-536 Sentence denotes In a recent study, inhibition of TLR responses by immunoreceptor tyrosine-based activation motif (ITAM)-coupled receptors was shown to depend on the expression of the NF-κB inhibitory proteins ABIN-3 and A20.
T12651 537-658 Sentence denotes Moreover, this protective effect of the ITAM was strongly suppressed in inflammatory arthritis synovial macrophages [60].
T135 537-658 Sentence denotes Moreover, this protective effect of the ITAM was strongly suppressed in inflammatory arthritis synovial macrophages [60].
T12652 659-782 Sentence denotes Interestingly, ABIN-1 polymorphisms have been associated with psoriasis and systemic lupus erythematosus in humans [61,62].
T136 659-782 Sentence denotes Interestingly, ABIN-1 polymorphisms have been associated with psoriasis and systemic lupus erythematosus in humans [61,62].
T12653 783-1066 Sentence denotes A high degree of overlap between systemic lupus erythematosus and RA susceptibility loci might be expected as the two diseases show some clinical overlap in joint involvement, autoantibody production, systemic features and response to treatments such as B-cell depletion (rituximab).
T137 783-1066 Sentence denotes A high degree of overlap between systemic lupus erythematosus and RA susceptibility loci might be expected as the two diseases show some clinical overlap in joint involvement, autoantibody production, systemic features and response to treatments such as B-cell depletion (rituximab).
T12654 1067-1231 Sentence denotes It will therefore be interesting to investigate whether SNPs that have been reported to be associated with systemic lupus erythematosus are also associated with RA.
T138 1067-1231 Sentence denotes It will therefore be interesting to investigate whether SNPs that have been reported to be associated with systemic lupus erythematosus are also associated with RA.