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PMC:2817507 / 9584-12023 JSONTXT 23 Projects

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Id Subject Object Predicate Lexical cue
T99 0-2 Sentence denotes 3.
T100 3-10 Sentence denotes Results
T4505 12-16 Sentence denotes 3.1.
T101 12-16 Sentence denotes 3.1.
T4506 17-62 Sentence denotes TLR4 mRNA Increased in Brain Tissue after ICH
T102 17-62 Sentence denotes TLR4 mRNA Increased in Brain Tissue after ICH
T4507 63-104 Sentence denotes TLR4 mRNA levels were detected by Rt-PCR.
T103 63-104 Sentence denotes TLR4 mRNA levels were detected by Rt-PCR.
T4508 105-172 Sentence denotes The low level of TLR4 mRNA was observed in normal rat brain tissue.
T104 105-172 Sentence denotes The low level of TLR4 mRNA was observed in normal rat brain tissue.
T4509 173-290 Sentence denotes In the saline control group, the TLR4 mRNA slightly increased, but was not significantly different from normal group.
T105 173-290 Sentence denotes In the saline control group, the TLR4 mRNA slightly increased, but was not significantly different from normal group.
T4510 291-564 Sentence denotes However, the TLR4 mRNA after ICH significantly increased starting from 6 hours after ICH (P < .05), peaked on the 3rd day after ICH, and then decreased on the 7th day after ICH (P < .05), but still maintained a higher level compared with saline control (P < .05, Figure 1).
T106 291-564 Sentence denotes However, the TLR4 mRNA after ICH significantly increased starting from 6 hours after ICH (P < .05), peaked on the 3rd day after ICH, and then decreased on the 7th day after ICH (P < .05), but still maintained a higher level compared with saline control (P < .05, Figure 1).
T4899 566-570 Sentence denotes 3.2.
T107 566-570 Sentence denotes 3.2.
T4900 571-633 Sentence denotes Expression of TLR4 Protein Increased in Brain Tissue after ICH
T108 571-633 Sentence denotes Expression of TLR4 Protein Increased in Brain Tissue after ICH
T4901 634-816 Sentence denotes To investigate the increased TLR4 at the protein level, the expression of TLR4 protein was measured in brain tissue by the method of Western Blots using specific antibodies for TLR4.
T109 634-816 Sentence denotes To investigate the increased TLR4 at the protein level, the expression of TLR4 protein was measured in brain tissue by the method of Western Blots using specific antibodies for TLR4.
T4902 817-912 Sentence denotes Our results showed that a low level of TLR4 protein was detectable in the saline control group.
T110 817-912 Sentence denotes Our results showed that a low level of TLR4 protein was detectable in the saline control group.
T4903 913-1137 Sentence denotes The expression of TLR4 significantly increased starting from 6 hours after ICH (P < .05), peaked on the 3rd day after ICH, and then decreased but still maintained at a high level on the 7th day after ICH (P < .05, Figure 2).
T111 913-1137 Sentence denotes The expression of TLR4 significantly increased starting from 6 hours after ICH (P < .05), peaked on the 3rd day after ICH, and then decreased but still maintained at a high level on the 7th day after ICH (P < .05, Figure 2).
T4904 1138-1239 Sentence denotes This observation of TLR4 protein was consistent with the temporal profile of the TLR4 mRNA after ICH.
T112 1138-1239 Sentence denotes This observation of TLR4 protein was consistent with the temporal profile of the TLR4 mRNA after ICH.
T5362 1241-1245 Sentence denotes 3.3.
T113 1241-1245 Sentence denotes 3.3.
T5363 1246-1292 Sentence denotes Distribution of TLR4 in Brain Subjected to ICH
T114 1246-1292 Sentence denotes Distribution of TLR4 in Brain Subjected to ICH
T5364 1293-1390 Sentence denotes To explore the distribution of TLR4 protein, the TLR4 was detected by immunohistochemistry (IHC).
T115 1293-1390 Sentence denotes To explore the distribution of TLR4 protein, the TLR4 was detected by immunohistochemistry (IHC).
T5365 1391-1497 Sentence denotes Results showed that TLR4 immunoreactivity was not detectable in brain tissue from normal and sham control.
T116 1391-1497 Sentence denotes Results showed that TLR4 immunoreactivity was not detectable in brain tissue from normal and sham control.
T5366 1498-1671 Sentence denotes However, immunoreactivity for TLR4 was consistently demonstrated in peri-hemorrhage areas, the hippocampus, cortex, thalamic nuclei, and some white matter tracts (Figure 3).
T117 1498-1671 Sentence denotes However, immunoreactivity for TLR4 was consistently demonstrated in peri-hemorrhage areas, the hippocampus, cortex, thalamic nuclei, and some white matter tracts (Figure 3).
T5607 1673-1677 Sentence denotes 3.4.
T118 1673-1677 Sentence denotes 3.4.
T5608 1678-1726 Sentence denotes Activation of TLR4-Mediated NF-Kappa-B Signaling
T119 1678-1726 Sentence denotes Activation of TLR4-Mediated NF-Kappa-B Signaling
T5609 1727-1850 Sentence denotes Activation of TLR4 induces the phosphorylation of inhibitor of kappa-B (IκB), which dissociates IκB with NF-kappa-B (NFκB).
T120 1727-1850 Sentence denotes Activation of TLR4 induces the phosphorylation of inhibitor of kappa-B (IκB), which dissociates IκB with NF-kappa-B (NFκB).
T5610 1851-1981 Sentence denotes Then, NFκB translocates into the nucleus and activates and regulates the transcription of genes related to inflammatory responses.
T121 1851-1981 Sentence denotes Then, NFκB translocates into the nucleus and activates and regulates the transcription of genes related to inflammatory responses.
T5611 1982-2165 Sentence denotes To detectd the activation of TLR4-mediated NFκB signaling, the phosphorylation of inhibitor of kappa-B (p-IκB) and activity of NFκB were measured by methods of Western Blots and EMSA.
T122 1982-2165 Sentence denotes To detectd the activation of TLR4-mediated NFκB signaling, the phosphorylation of inhibitor of kappa-B (p-IκB) and activity of NFκB were measured by methods of Western Blots and EMSA.
T5612 2166-2334 Sentence denotes Results showed that the p-IκB increased at 6 hours after ICH (P < .05), peaked on 3 days after ICH, and maintained a high level on 7 days after ICH (P < .05, Figure 5).
T123 2166-2334 Sentence denotes Results showed that the p-IκB increased at 6 hours after ICH (P < .05), peaked on 3 days after ICH, and maintained a high level on 7 days after ICH (P < .05, Figure 5).
T5613 2335-2439 Sentence denotes As expected, the activity of NFκB was also increased in the same manner as that of the p-IκB (Figure 4).
T124 2335-2439 Sentence denotes As expected, the activity of NFκB was also increased in the same manner as that of the p-IκB (Figure 4).