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PMC:2817507 / 2136-3529 JSONTXT 25 Projects

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Id Subject Object Predicate Lexical cue
T842 0-89 Sentence denotes TLRs are a family of transmembrane proteins and act as signal transduction molecules [4].
T17 0-89 Sentence denotes TLRs are a family of transmembrane proteins and act as signal transduction molecules [4].
T843 90-250 Sentence denotes Activation of TLRs recruits downstream signaling proteins and results in transcription of genes encoding inflammation-associated molecules and cytokines [5, 6].
T18 90-250 Sentence denotes Activation of TLRs recruits downstream signaling proteins and results in transcription of genes encoding inflammation-associated molecules and cytokines [5, 6].
T844 251-419 Sentence denotes For example, combined with specific ligand, the activation of TLR4 induces the phosphorylation of inhibitor of kappa-B (IκB) and dissociates IκB from NF-kappa-B (NFκB).
T19 251-419 Sentence denotes For example, combined with specific ligand, the activation of TLR4 induces the phosphorylation of inhibitor of kappa-B (IκB) and dissociates IκB from NF-kappa-B (NFκB).
T845 420-558 Sentence denotes Then, NFκB trans-locates into the nucleus and activates and regulates the transcription of genes related to inflammatory responses [5, 6].
T20 420-558 Sentence denotes Then, NFκB trans-locates into the nucleus and activates and regulates the transcription of genes related to inflammatory responses [5, 6].
T846 559-767 Sentence denotes TLRs play a critical role in the induction of immunological/inflammatory responses and are implicated in several CNS diseases, such as infectious disease, autoimmune disease, and ischemic brain injury [7, 8].
T21 559-767 Sentence denotes TLRs play a critical role in the induction of immunological/inflammatory responses and are implicated in several CNS diseases, such as infectious disease, autoimmune disease, and ischemic brain injury [7, 8].
T847 768-1000 Sentence denotes Accumulating evidences demonstrate that TLR4, the first mammalian TLR recognized, contributes to the neuronal death, blood brain barrier damage, brain edema, and inflammatory responses in the brain injury induced by ischemia [8, 9].
T22 768-1000 Sentence denotes Accumulating evidences demonstrate that TLR4, the first mammalian TLR recognized, contributes to the neuronal death, blood brain barrier damage, brain edema, and inflammatory responses in the brain injury induced by ischemia [8, 9].
T848 1001-1060 Sentence denotes However, little is known about TLR4 in the brain after ICH.
T23 1001-1060 Sentence denotes However, little is known about TLR4 in the brain after ICH.
T849 1061-1220 Sentence denotes In the present study, we detected the transcription of TLR4 gene and the activation of TLR4-mediated signaling in the rat brains subjected to experimental ICH.
T24 1061-1220 Sentence denotes In the present study, we detected the transcription of TLR4 gene and the activation of TLR4-mediated signaling in the rat brains subjected to experimental ICH.
T850 1221-1392 Sentence denotes Our data firstly provided the knowledge about the distribution of TLR4 and the temporal profile of the activation of TLR4-mediated signaling in rat brain tissue after ICH.
T25 1221-1392 Sentence denotes Our data firstly provided the knowledge about the distribution of TLR4 and the temporal profile of the activation of TLR4-mediated signaling in rat brain tissue after ICH.