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PMC:2817507 / 1381-3528 JSONTXT 25 Projects

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Id Subject Object Predicate Lexical cue
T11 0-2 Sentence denotes 1.
T12 3-15 Sentence denotes Introduction
T838 16-268 Sentence denotes Intracerebral hemorrhage (ICH) represents 10%–15% of all strokes and occurs with increasing frequency as a complication of the thrombolytic treatment of ischemic stroke, which is associated with high mortality and severe disability in survivors [1, 2].
T13 16-268 Sentence denotes Intracerebral hemorrhage (ICH) represents 10%–15% of all strokes and occurs with increasing frequency as a complication of the thrombolytic treatment of ischemic stroke, which is associated with high mortality and severe disability in survivors [1, 2].
T839 269-488 Sentence denotes Local brain tissue deformation induces primary brain damage after ICH; more importantly, the excitotoxicity and inflammatory responses in the brain tissue induced by ICH result in further brain damage following ICH [3].
T14 269-488 Sentence denotes Local brain tissue deformation induces primary brain damage after ICH; more importantly, the excitotoxicity and inflammatory responses in the brain tissue induced by ICH result in further brain damage following ICH [3].
T840 489-648 Sentence denotes Both innate and adaptive immunological/inflammatory mechanisms have been clearly shown to participate in the progression of brain injury after ischemic stroke.
T15 489-648 Sentence denotes Both innate and adaptive immunological/inflammatory mechanisms have been clearly shown to participate in the progression of brain injury after ischemic stroke.
T841 649-754 Sentence denotes Nevertheless, how the inflammatory responses in ICH are triggered and regulated remains to be elucidated.
T16 649-754 Sentence denotes Nevertheless, how the inflammatory responses in ICH are triggered and regulated remains to be elucidated.
T842 755-844 Sentence denotes TLRs are a family of transmembrane proteins and act as signal transduction molecules [4].
T17 755-844 Sentence denotes TLRs are a family of transmembrane proteins and act as signal transduction molecules [4].
T843 845-1005 Sentence denotes Activation of TLRs recruits downstream signaling proteins and results in transcription of genes encoding inflammation-associated molecules and cytokines [5, 6].
T18 845-1005 Sentence denotes Activation of TLRs recruits downstream signaling proteins and results in transcription of genes encoding inflammation-associated molecules and cytokines [5, 6].
T844 1006-1174 Sentence denotes For example, combined with specific ligand, the activation of TLR4 induces the phosphorylation of inhibitor of kappa-B (IκB) and dissociates IκB from NF-kappa-B (NFκB).
T19 1006-1174 Sentence denotes For example, combined with specific ligand, the activation of TLR4 induces the phosphorylation of inhibitor of kappa-B (IκB) and dissociates IκB from NF-kappa-B (NFκB).
T845 1175-1313 Sentence denotes Then, NFκB trans-locates into the nucleus and activates and regulates the transcription of genes related to inflammatory responses [5, 6].
T20 1175-1313 Sentence denotes Then, NFκB trans-locates into the nucleus and activates and regulates the transcription of genes related to inflammatory responses [5, 6].
T846 1314-1522 Sentence denotes TLRs play a critical role in the induction of immunological/inflammatory responses and are implicated in several CNS diseases, such as infectious disease, autoimmune disease, and ischemic brain injury [7, 8].
T21 1314-1522 Sentence denotes TLRs play a critical role in the induction of immunological/inflammatory responses and are implicated in several CNS diseases, such as infectious disease, autoimmune disease, and ischemic brain injury [7, 8].
T847 1523-1755 Sentence denotes Accumulating evidences demonstrate that TLR4, the first mammalian TLR recognized, contributes to the neuronal death, blood brain barrier damage, brain edema, and inflammatory responses in the brain injury induced by ischemia [8, 9].
T22 1523-1755 Sentence denotes Accumulating evidences demonstrate that TLR4, the first mammalian TLR recognized, contributes to the neuronal death, blood brain barrier damage, brain edema, and inflammatory responses in the brain injury induced by ischemia [8, 9].
T848 1756-1815 Sentence denotes However, little is known about TLR4 in the brain after ICH.
T23 1756-1815 Sentence denotes However, little is known about TLR4 in the brain after ICH.
T849 1816-1975 Sentence denotes In the present study, we detected the transcription of TLR4 gene and the activation of TLR4-mediated signaling in the rat brains subjected to experimental ICH.
T24 1816-1975 Sentence denotes In the present study, we detected the transcription of TLR4 gene and the activation of TLR4-mediated signaling in the rat brains subjected to experimental ICH.
T850 1976-2147 Sentence denotes Our data firstly provided the knowledge about the distribution of TLR4 and the temporal profile of the activation of TLR4-mediated signaling in rat brain tissue after ICH.
T25 1976-2147 Sentence denotes Our data firstly provided the knowledge about the distribution of TLR4 and the temporal profile of the activation of TLR4-mediated signaling in rat brain tissue after ICH.