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PMC:1942070 / 13152-15134 JSONTXT 20 Projects

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Id Subject Object Predicate Lexical cue
T86 0-13 Sentence denotes 4 Discussion
T87 14-210 Sentence denotes Protein kinase D serine kinases have been proposed to regulate diverse cellular functions including the phosphorylation and nuclear localisation of class II HDACs and the phosphorylation of HSP27.
T7008 211-360 Sentence denotes It has also been suggested that PKDs act as mitochondrial sensors for oxidative stress and play a role in regulating NFκB transcription factors [41].
T88 211-360 Sentence denotes It has also been suggested that PKDs act as mitochondrial sensors for oxidative stress and play a role in regulating NFκB transcription factors [41].
T7009 361-531 Sentence denotes Most of the data about the function of PKDs has come from experiments that ectopically express active or inhibitory PKD mutants or that use RNAi to reduce PKD expression.
T89 361-531 Sentence denotes Most of the data about the function of PKDs has come from experiments that ectopically express active or inhibitory PKD mutants or that use RNAi to reduce PKD expression.
T7010 532-813 Sentence denotes We have used gene targeting to specifically delete PKD alleles in DT40 chicken B cells and can thus use PKD-null DT40 cells to assess the relative contribution of individual PKD isoforms in class II HDAC control versus oxidative stress responses and NFκB regulation in lymphocytes.
T90 532-813 Sentence denotes We have used gene targeting to specifically delete PKD alleles in DT40 chicken B cells and can thus use PKD-null DT40 cells to assess the relative contribution of individual PKD isoforms in class II HDAC control versus oxidative stress responses and NFκB regulation in lymphocytes.
T7011 814-1141 Sentence denotes We have previously used these PKD-null DT40 cells to define an essential role for PKDs in regulation of class II HDACs, the present report now describes an indispensable role for PKDs in regulating the phosphorylation of HSP27 on serine 82, a site previously identified as a target for the p38-MAPKAPK2 signalling cascade [42].
T91 814-1141 Sentence denotes We have previously used these PKD-null DT40 cells to define an essential role for PKDs in regulation of class II HDACs, the present report now describes an indispensable role for PKDs in regulating the phosphorylation of HSP27 on serine 82, a site previously identified as a target for the p38-MAPKAPK2 signalling cascade [42].
T7012 1142-1338 Sentence denotes However, studies of PKD-null DT40 cells reveal that PKD family kinases are not essential for oxidative stress survival responses nor are they required for activation of NFκB transcription factors.
T92 1142-1338 Sentence denotes However, studies of PKD-null DT40 cells reveal that PKD family kinases are not essential for oxidative stress survival responses nor are they required for activation of NFκB transcription factors.
T7013 1339-1575 Sentence denotes These latter findings are in striking contrast to previous observations in HeLa and epithelial cell lines where overexpression/RNAi approaches have implicated PKD1/2 in the control of proliferation, survival and NFκB activation [20,23].
T93 1339-1575 Sentence denotes These latter findings are in striking contrast to previous observations in HeLa and epithelial cell lines where overexpression/RNAi approaches have implicated PKD1/2 in the control of proliferation, survival and NFκB activation [20,23].
T7014 1576-1831 Sentence denotes Hence, the present report shows that the proposed roles for PKDs as key sensors that modulate survival pathways in response to oxidative stress and regulate cell survival and proliferation are not ubiquitous and may be restricted to certain cell lineages.
T94 1576-1831 Sentence denotes Hence, the present report shows that the proposed roles for PKDs as key sensors that modulate survival pathways in response to oxidative stress and regulate cell survival and proliferation are not ubiquitous and may be restricted to certain cell lineages.
T7015 1832-1982 Sentence denotes Taken together, these data indicate that loss of expression of PKD family members does not globally impact on early BCR-regulated signalling pathways.
T95 1832-1982 Sentence denotes Taken together, these data indicate that loss of expression of PKD family members does not globally impact on early BCR-regulated signalling pathways.