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PMC:1310901 / 1798-5127 JSONTXT 17 Projects

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Id Subject Object Predicate Lexical cue
T11 0-12 Sentence denotes INTRODUCTION
T1054 13-284 Sentence denotes Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder with a typical three phased course (chronic, accelerated and blastic phase) reflecting the loss of differentiation and malignant progress which inevitably leads to death after the blastic phase (1,2).
T12 13-284 Sentence denotes Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder with a typical three phased course (chronic, accelerated and blastic phase) reflecting the loss of differentiation and malignant progress which inevitably leads to death after the blastic phase (1,2).
T1055 285-464 Sentence denotes The hallmark genetic aberration of CML is a reciprocal chromosomal translocation t(9;22) leading to expression of a bcr-abl fusion gene, an aberrant activated tyrosine kinase (2).
T13 285-464 Sentence denotes The hallmark genetic aberration of CML is a reciprocal chromosomal translocation t(9;22) leading to expression of a bcr-abl fusion gene, an aberrant activated tyrosine kinase (2).
T1056 465-621 Sentence denotes Treatment with interferon α (IFN-α) prolongs survival of CML patients and is associated with a complete cytogenetic response in 5–33% of CML patients (1,2).
T14 465-621 Sentence denotes Treatment with interferon α (IFN-α) prolongs survival of CML patients and is associated with a complete cytogenetic response in 5–33% of CML patients (1,2).
T1057 622-776 Sentence denotes Recently, we described an impaired expression of the interferon regulatory factor 4 (IRF-4) in CML, correlating with poor response to IFN-α treatment (3).
T15 622-776 Sentence denotes Recently, we described an impaired expression of the interferon regulatory factor 4 (IRF-4) in CML, correlating with poor response to IFN-α treatment (3).
T1058 777-836 Sentence denotes The cause of the silencing of IRF-4 level remained unclear.
T16 777-836 Sentence denotes The cause of the silencing of IRF-4 level remained unclear.
T1059 837-982 Sentence denotes Interferon regulatory factors (IRFs) are a family of transcriptional regulators defined by a characteristic homology in their DNA-binding domain.
T17 837-982 Sentence denotes Interferon regulatory factors (IRFs) are a family of transcriptional regulators defined by a characteristic homology in their DNA-binding domain.
T1060 983-1139 Sentence denotes They play an important role in the regulation of various genes (such as IFNs, interleukins, MHC class I/II), apoptosis and differentiation/maturation (4–6).
T18 983-1139 Sentence denotes They play an important role in the regulation of various genes (such as IFNs, interleukins, MHC class I/II), apoptosis and differentiation/maturation (4–6).
T1061 1140-1223 Sentence denotes IRF-4 (ICSAT/Pip/MUM1/LSIRF) is one member with very restricted expression pattern:
T19 1140-1223 Sentence denotes IRF-4 (ICSAT/Pip/MUM1/LSIRF) is one member with very restricted expression pattern:
T1062 1224-1295 Sentence denotes Predominately B- and activated T-lymphocytes are IRF-4 positive (7–11).
T20 1224-1295 Sentence denotes Predominately B- and activated T-lymphocytes are IRF-4 positive (7–11).
T1063 1296-1474 Sentence denotes In contrast to other IRFs, expression of IRF-4 cannot be induced by IFNs, but by antigen stimulation, crosslinking of T- or B-cell receptors or phorbol-myristate-acetate (10,11).
T21 1296-1474 Sentence denotes In contrast to other IRFs, expression of IRF-4 cannot be induced by IFNs, but by antigen stimulation, crosslinking of T- or B-cell receptors or phorbol-myristate-acetate (10,11).
T1064 1475-1734 Sentence denotes Consistent with the restriction of expression to immunocompetent cells, mice with deletion of IRF-4 failed to develop mature and functionally active B- and T-lymphocytes (12), and the impaired expression of IRF-4 in CML was predominately found in T-cells (3).
T22 1475-1734 Sentence denotes Consistent with the restriction of expression to immunocompetent cells, mice with deletion of IRF-4 failed to develop mature and functionally active B- and T-lymphocytes (12), and the impaired expression of IRF-4 in CML was predominately found in T-cells (3).
T1065 1735-1811 Sentence denotes These data suggest a crucial role for IRF-4 in the function of immune cells.
T23 1735-1811 Sentence denotes These data suggest a crucial role for IRF-4 in the function of immune cells.
T1066 1812-2048 Sentence denotes Methylation of dinucleotide cytosine-guanosine motifs (CpG), especially in CpG islands located in promoter regions, is one of the mechanisms of gene regulation in mammals and a common event of gene silencing in human neoplasias (13,14).
T24 1812-2048 Sentence denotes Methylation of dinucleotide cytosine-guanosine motifs (CpG), especially in CpG islands located in promoter regions, is one of the mechanisms of gene regulation in mammals and a common event of gene silencing in human neoplasias (13,14).
T1067 2049-2166 Sentence denotes As opposed to normal cells, hypermethylation of CpG islands is a frequently observed phenomenon in every cancer type.
T25 2049-2166 Sentence denotes As opposed to normal cells, hypermethylation of CpG islands is a frequently observed phenomenon in every cancer type.
T1068 2167-2330 Sentence denotes De novo DNA methylation of genes such as cell cycle, DNA repair, apoptosis and tumor suppressor genes is therefore thought to be involved in tumorigenesis (15–17).
T26 2167-2330 Sentence denotes De novo DNA methylation of genes such as cell cycle, DNA repair, apoptosis and tumor suppressor genes is therefore thought to be involved in tumorigenesis (15–17).
T1069 2331-2441 Sentence denotes Examples for such aberrated genes are MGMT, DAPK, p14ARF, p15INK4b, p16INK4a, BRCA1, CDH13 and APAF-1 (17–19).
T27 2331-2441 Sentence denotes Examples for such aberrated genes are MGMT, DAPK, p14ARF, p15INK4b, p16INK4a, BRCA1, CDH13 and APAF-1 (17–19).
T1070 2442-2652 Sentence denotes In CML, methylation is known to regulate expression of the c-abl, the bcr gene and others (20–23), and the extent of methylation in the c-abl promoter has been shown to be associated with advanced disease (24).
T28 2442-2652 Sentence denotes In CML, methylation is known to regulate expression of the c-abl, the bcr gene and others (20–23), and the extent of methylation in the c-abl promoter has been shown to be associated with advanced disease (24).
T1071 2653-2800 Sentence denotes Hypermethylation due to overexpression of DNA methyltransferases (DNMTs) remains one possible explanation for de novo methylation in tumorigenesis.
T29 2653-2800 Sentence denotes Hypermethylation due to overexpression of DNA methyltransferases (DNMTs) remains one possible explanation for de novo methylation in tumorigenesis.
T1072 2801-2887 Sentence denotes Recently, DNMTs have been shown to be up-regulated in hematopoietic malignancies (25).
T30 2801-2887 Sentence denotes Recently, DNMTs have been shown to be up-regulated in hematopoietic malignancies (25).
T1073 2888-3099 Sentence denotes Methyl-CpG-binding proteins (MBPs) are thought to inhibit the binding of transcriptional factors to the promoter and are therefore discussed as one mechanism of transcription inhibition by hypermethylation (26).
T31 2888-3099 Sentence denotes Methyl-CpG-binding proteins (MBPs) are thought to inhibit the binding of transcriptional factors to the promoter and are therefore discussed as one mechanism of transcription inhibition by hypermethylation (26).
T1074 3100-3189 Sentence denotes In this work, we studied mechanisms of IRF-4 gene expression silencing in leukemic cells.
T32 3100-3189 Sentence denotes In this work, we studied mechanisms of IRF-4 gene expression silencing in leukemic cells.
T1075 3190-3329 Sentence denotes We analyzed the IRF-4 promoter region for genetic aberrations and methylational status in IRF-4-positive and -negative hematopoietic cells.
T33 3190-3329 Sentence denotes We analyzed the IRF-4 promoter region for genetic aberrations and methylational status in IRF-4-positive and -negative hematopoietic cells.