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PMC:1134658 / 1403-4028 JSONTXT 17 Projects

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Id Subject Object Predicate Lexical cue
T16 0-10 Sentence denotes Background
T1034 11-178 Sentence denotes Members of the transforming growth factor β (TGF-β) superfamily play central roles in controlling cellular proliferation, differentiation, migration and apoptosis [1].
T17 11-178 Sentence denotes Members of the transforming growth factor β (TGF-β) superfamily play central roles in controlling cellular proliferation, differentiation, migration and apoptosis [1].
T1035 179-356 Sentence denotes These cytokines can be divided into three subgroups: TGF-β, the activins/inhibins, and the bone morphogenetic proteins (BMPs), of which the latter constitute the largest family.
T18 179-356 Sentence denotes These cytokines can be divided into three subgroups: TGF-β, the activins/inhibins, and the bone morphogenetic proteins (BMPs), of which the latter constitute the largest family.
T1036 357-500 Sentence denotes BMPs are 30–38 kDa hetero- or homodimeric proteins originally identified by their ability to induce ectopic cartilage and bone formation [2,3].
T19 357-500 Sentence denotes BMPs are 30–38 kDa hetero- or homodimeric proteins originally identified by their ability to induce ectopic cartilage and bone formation [2,3].
T1037 501-638 Sentence denotes Several studies have demonstrated an essential role of these proteins during embryogenesis, and more recently, also in adult tissues [1].
T20 501-638 Sentence denotes Several studies have demonstrated an essential role of these proteins during embryogenesis, and more recently, also in adult tissues [1].
T1038 639-799 Sentence denotes TGF-β has been intensively studied in normal and malignant haematopoietic cells and is one of the most potent endogenous negative regulators known to date. [4].
T21 639-799 Sentence denotes TGF-β has been intensively studied in normal and malignant haematopoietic cells and is one of the most potent endogenous negative regulators known to date. [4].
T1039 800-886 Sentence denotes In contrast, the effect of BMPs in the immune system has not been widely investigated.
T22 800-886 Sentence denotes In contrast, the effect of BMPs in the immune system has not been widely investigated.
T1040 887-1032 Sentence denotes In that respect, BMP- 2, -4 and -7 have been found to control differentiation of hematopoietic stem cells [5] and early T cell development [6,7].
T23 887-1032 Sentence denotes In that respect, BMP- 2, -4 and -7 have been found to control differentiation of hematopoietic stem cells [5] and early T cell development [6,7].
T1041 1033-1153 Sentence denotes BMP-6 has been reported to reduce the number of cobblestone-area-forming cells of normal human haematopoietic cells [8].
T24 1033-1153 Sentence denotes BMP-6 has been reported to reduce the number of cobblestone-area-forming cells of normal human haematopoietic cells [8].
T1042 1154-1271 Sentence denotes Furthermore, BMP-2, -4, 6 and -7 had an antiproliferative and a proapoptotic effect on multiple myeloma cells [9-11].
T25 1154-1271 Sentence denotes Furthermore, BMP-2, -4, 6 and -7 had an antiproliferative and a proapoptotic effect on multiple myeloma cells [9-11].
T1043 1272-1484 Sentence denotes In addition, by gene expression profiling, BMP-6 significantly increased the predictive value for a multi-gene signature test and was associated with a poor outcome in diffuse large B cell lymphomas (DLBCL) [12].
T26 1272-1484 Sentence denotes In addition, by gene expression profiling, BMP-6 significantly increased the predictive value for a multi-gene signature test and was associated with a poor outcome in diffuse large B cell lymphomas (DLBCL) [12].
T1044 1485-1741 Sentence denotes BMP-6, like the other BMP members, signals through ligation and heterodimerzation of BMP type I [activin-like-kinase (ALK)] and type II serine-threonine kinase receptors, which subsequently propagates the signal downstream by phosphorylating Smad proteins.
T27 1485-1741 Sentence denotes BMP-6, like the other BMP members, signals through ligation and heterodimerzation of BMP type I [activin-like-kinase (ALK)] and type II serine-threonine kinase receptors, which subsequently propagates the signal downstream by phosphorylating Smad proteins.
T1045 1742-1977 Sentence denotes BMP-6 can signal through the ligation of the type I receptors Act-RIA, BMP-RIA, and BMP-RIB and the type II receptors BMP-RII, Act-RIIA and Act-RIIB, which lead to the phosphorylation of the receptor Smads (Smad-1, Smad-5, and Smad-8).
T28 1742-1977 Sentence denotes BMP-6 can signal through the ligation of the type I receptors Act-RIA, BMP-RIA, and BMP-RIB and the type II receptors BMP-RII, Act-RIIA and Act-RIIB, which lead to the phosphorylation of the receptor Smads (Smad-1, Smad-5, and Smad-8).
T1046 1978-2114 Sentence denotes The R- Smads then form complexes with the co-Smad (Smad4) and are translocated into the nucleus where they exert gene regulation [1,13].
T29 1978-2114 Sentence denotes The R- Smads then form complexes with the co-Smad (Smad4) and are translocated into the nucleus where they exert gene regulation [1,13].
T1047 2115-2272 Sentence denotes Given the reported role of BMP-6 in B-cell malignancies and haematopoietic progenitor cells, we wanted to explore its potential role in normal human B cells.
T30 2115-2272 Sentence denotes Given the reported role of BMP-6 in B-cell malignancies and haematopoietic progenitor cells, we wanted to explore its potential role in normal human B cells.
T1048 2273-2370 Sentence denotes We studied the effects of BMP-6 on proliferation and apoptosis on resting and stimulated B cells.
T31 2273-2370 Sentence denotes We studied the effects of BMP-6 on proliferation and apoptosis on resting and stimulated B cells.
T1049 2371-2546 Sentence denotes Furthermore, the expression of BMP receptors and BMP-6 induced activation of the Smad signalling pathway with subsequent regulation of the target genes Id1–Id4, were resolved.
T32 2371-2546 Sentence denotes Furthermore, the expression of BMP receptors and BMP-6 induced activation of the Smad signalling pathway with subsequent regulation of the target genes Id1–Id4, were resolved.
T1050 2547-2625 Sentence denotes Finally, we investigated whether B cells also were capable of producing BMP-6.
T33 2547-2625 Sentence denotes Finally, we investigated whether B cells also were capable of producing BMP-6.