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PMC:1134658 / 10196-11506 JSONTXT 17 Projects

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Id Subject Object Predicate Lexical cue
T6481 0-27 Sentence denotes BMP-6 production in B cells
T84 0-27 Sentence denotes BMP-6 production in B cells
T6482 28-232 Sentence denotes The fact that BMP-6 has been reported to act as an autocrine stimulator in chondrocytes [18] and ovarium [19], prompted us to investigate whether normal human B cells could produce BMP-6 upon stimulation.
T85 28-232 Sentence denotes The fact that BMP-6 has been reported to act as an autocrine stimulator in chondrocytes [18] and ovarium [19], prompted us to investigate whether normal human B cells could produce BMP-6 upon stimulation.
T6483 233-396 Sentence denotes Ramos cells, which have been described to express BMP-6 mRNA endogenously [20], and the T cell line Jurkat, served as positive and negative controls, respectively.
T86 233-396 Sentence denotes Ramos cells, which have been described to express BMP-6 mRNA endogenously [20], and the T cell line Jurkat, served as positive and negative controls, respectively.
T6484 397-538 Sentence denotes Endogenous BMP-6 mRNA levels in normal B cells were quantified by real-time RT-PCR after stimulation with anti-IgM for different time points.
T87 397-538 Sentence denotes Endogenous BMP-6 mRNA levels in normal B cells were quantified by real-time RT-PCR after stimulation with anti-IgM for different time points.
T6485 539-716 Sentence denotes Interestingly, the up-regulation of BMP-6 mRNA was characteristic of an early-to intermediate inducible gene with maximal upregulation four hours after the addition of anti-IgM.
T88 539-716 Sentence denotes Interestingly, the up-regulation of BMP-6 mRNA was characteristic of an early-to intermediate inducible gene with maximal upregulation four hours after the addition of anti-IgM.
T6486 717-806 Sentence denotes The level of BMP-6 mRNA was back to baseline after 24 hours upon stimulation (Figure 10).
T89 717-806 Sentence denotes The level of BMP-6 mRNA was back to baseline after 24 hours upon stimulation (Figure 10).
T6487 807-907 Sentence denotes Furthermore, both FCS and human AB-serum induced significant upregulation of BMP-6 mRNA (Figure 11).
T90 807-907 Sentence denotes Furthermore, both FCS and human AB-serum induced significant upregulation of BMP-6 mRNA (Figure 11).
T6488 908-1071 Sentence denotes Interestingly, in a separate study we have found that normal human T cells do not express BMP-6 mRNA after activation (Sivertsen et al, manuscript in preparation).
T91 908-1071 Sentence denotes Interestingly, in a separate study we have found that normal human T cells do not express BMP-6 mRNA after activation (Sivertsen et al, manuscript in preparation).
T6489 1072-1183 Sentence denotes Next, we wanted to detect BMP-6 protein in normal B-cells and tested various commercially available antibodies.
T92 1072-1183 Sentence denotes Next, we wanted to detect BMP-6 protein in normal B-cells and tested various commercially available antibodies.
T6490 1184-1310 Sentence denotes However, in our hands these anti-BMP-6 antibodies did only recognize the recombinant BMP-6 protein and not the native protein.
T93 1184-1310 Sentence denotes However, in our hands these anti-BMP-6 antibodies did only recognize the recombinant BMP-6 protein and not the native protein.