| Id |
Subject |
Object |
Predicate |
Lexical cue |
| S1 |
0-152 |
Sentence |
denotes |
Mildly oxidized low-density lipoproteins decrease early production of interleukin 2 and nuclear factor kappaB binding to DNA in activated T-lymphocytes. |
| S2 |
153-258 |
Sentence |
denotes |
Activated T-lymphocytes are found early in atherosclerosis lesions, but little is known about their role. |
| S3 |
259-552 |
Sentence |
denotes |
Oxidized low-density lipoproteins (oxLDLs) are considered to be involved in the pathogenesis of the lesions, and we have previously demonstrated that oxLDLs inhibit not only interleukin (IL)-2-receptor expression on the surface of in vitro-activated T-lymphocytes but also their proliferation. |
| S4 |
553-738 |
Sentence |
denotes |
We have now investigated the effect of oxLDLs on blast differentiation, on IL-2 synthesis and on the activation of the nuclear factor kappaB (NF-kappaB) system in activated lymphocytes. |
| S5 |
739-953 |
Sentence |
denotes |
Mildly oxLDLs (50 and 100 microgram/ml) decreased the number of lymphoblasts and the level of IL-2 concentration in the culture supernatants after activation of lymphocytes by phytohaemagglutinin and PMA+ionomycin. |
| S6 |
954-1088 |
Sentence |
denotes |
The inhibition of IL-2 production was observed in the CD3(+) T-lymphocyte cytoplasm as early as 4 h after activation by PMA+ionomycin. |
| S7 |
1089-1298 |
Sentence |
denotes |
The study of NF-kappaB showed that oxLDLs led to a decrease of activation-induced p65/p50 NF-kappaB heterodimer binding to DNA, whereas the presence of the constitutive nuclear form of p50 dimer was unchanged. |
| S8 |
1299-1411 |
Sentence |
denotes |
This was correlated with an unchanged level of the active form of the cytosolic inhibitor protein IkappaB-alpha. |
| S9 |
1412-1575 |
Sentence |
denotes |
Taken together, these observations suggest that the immunosuppressive effect of oxLDLs might operate via a dysregulation of the T-lymphocyte activation mechanisms. |
