pubmed-sentences-benchmark  

PubMed:9864163 JSONTXT 8 Projects

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Id Subject Object Predicate Lexical cue
S1 0-114 Sentence denotes Mechanism of interleukin-10 inhibition of T-helper cell activation by superantigen at the level of the cell cycle.
S2 115-305 Sentence denotes We have analyzed the effects of interleukin-10 (IL-10) on the entry of quiescent CD4(+) T cells into the cell cycle upon stimulation with the superantigen staphylococcal enterotoxin B (SEB).
S3 306-336 Sentence denotes IL-10 arrested cells at G0/G1.
S4 337-482 Sentence denotes IL-10 treatment prevented the downregulation of p27(Kip1), an inhibitory protein that controls progression out of the G0 phase of the cell cycle.
S5 483-634 Sentence denotes IL-10 also prevented the upregulation of the G1 cyclins D2 and D3, proteins necessary for entry and progression through the G1 phase of the cell cycle.
S6 635-740 Sentence denotes Associated with the inhibition of the cell cycle, IL-10 suppressed SEB induction of interleukin-2 (IL-2).
S7 741-853 Sentence denotes Addition of exogenous IL-2 to IL-10-treated cells significantly reversed the antiproliferative effects of IL-10.
S8 854-969 Sentence denotes Moreover, IL-10 effects on the early G1 proteins p27(Kip1) and cyclin D2 were similarly reversed by exogenous IL-2.
S9 970-1141 Sentence denotes Although this reversal by IL-2 was pronounced, it was not complete, suggesting that IL-10 may have some effects not directly related to the suppression of IL-2 production.
S10 1142-1318 Sentence denotes Cell separation experiments suggest that IL-10 can effect purified CD4(+) T cells directly, providing functional evidence for the presence of IL-10 receptors on CD4(+) T cells.
S11 1319-1443 Sentence denotes IL-10 also inhibited expression of IL-2 transcriptional regulators c-fos and c-jun, which also inhibit other cell functions.
S12 1444-1707 Sentence denotes Our studies show that the mechanism of IL-10 regulation of quiescent CD4(+) T-cell activation is mainly by blocking induction of IL-2 that is critical to downregulation of p27(Kip1) and upregulation of D cyclins in T-cell activation and entry into the cell cycle.