| Id |
Subject |
Object |
Predicate |
Lexical cue |
| S1 |
0-108 |
Sentence |
denotes |
Spi-1/PU.1 proto-oncogene induces opposite effects on monocytic and erythroid differentiation of K562 cells. |
| S2 |
109-178 |
Sentence |
denotes |
Spi-1/PU.1 is a hematopoietic transcription factor of the Ets family. |
| S3 |
179-369 |
Sentence |
denotes |
To analyze the effects of ectopic expression of spi-1 on the proliferation/differentiation of human myeloid leukemia cells, K562 cells were stably transfected with a spi-1 expression vector. |
| S4 |
370-485 |
Sentence |
denotes |
The transfected cell lines expressed elevated levels of spi-1 mRNA and protein and high Spi-1-DNA binding activity. |
| S5 |
486-577 |
Sentence |
denotes |
The spi-1 transfected cells showed reduced growth rates and reduced clonogenic cell growth. |
| S6 |
578-855 |
Sentence |
denotes |
When the erythroid and monocytic differentiation markers were analyzed, spi-1 overexpression resulted in opposite effects: erythroid differentiation was significantly inhibited in spi-1 transfectants, while spi-1 overexpression increased the monocytic differentiation of cells. |
| S7 |
856-963 |
Sentence |
denotes |
These results indicate a differential role of Spi-1 on the differentiation of human myeloid leukemia cells. |
