| Id |
Subject |
Object |
Predicate |
Lexical cue |
| S1 |
0-105 |
Sentence |
denotes |
The interleukin 2 receptor alpha chain/CD25 promoter is a target for nuclear factor of activated T cells. |
| S2 |
106-253 |
Sentence |
denotes |
The expression of the murine interleukin (IL)-2 receptor alpha chain/CD25 is strongly induced at the transcriptional level after T cell activation. |
| S3 |
254-389 |
Sentence |
denotes |
We show here that nuclear factor of activated T cell (NF-AT) factors are involved in the control of CD25 promoter induction in T cells. |
| S4 |
390-504 |
Sentence |
denotes |
NF-ATp and NF-ATc bind to two sites around positions -585 and -650 located upstream of the proximal CD25 promoter. |
| S5 |
505-613 |
Sentence |
denotes |
Immediately 3' from these NF-AT motifs, nonconsensus sites are located for the binding of AP-1-like factors. |
| S6 |
614-757 |
Sentence |
denotes |
Mutations of sites that suppress NF-AT binding impair the induction and strong NF-ATp-mediated transactivation of the CD25 promoter in T cells. |
| S7 |
758-938 |
Sentence |
denotes |
In T lymphocytes from NF-ATp-deficient mice, the expression of CD25 is severely impaired, leading to a delayed IL-2 receptor expression after T cell receptor (TCR)/CD3 stimulation. |
| S8 |
939-1190 |
Sentence |
denotes |
Our data indicate an important role for NF-AT in the faithful expression of high affinity IL-2 receptors and a close link between the TCR-mediated induction of IL-2 and IL-2 receptor alpha chain promoters, both of which are regulated by NF-AT factors. |
