| Id |
Subject |
Object |
Predicate |
Lexical cue |
| S1 |
0-98 |
Sentence |
denotes |
HIV-1 Vpr suppresses immune activation and apoptosis through regulation of nuclear factor kappa B. |
| S2 |
99-253 |
Sentence |
denotes |
The HIV-1 accessory gene product Vpr can influence viral pathogenesis by affecting viral replication as well as host cell transcription and proliferation. |
| S3 |
254-372 |
Sentence |
denotes |
We have investigated the effects of Vpr on host cell activation and confirm that it influences cellular proliferation. |
| S4 |
373-509 |
Sentence |
denotes |
However, we have also found that Vpr modulates T-cell receptor (TCR)-triggered apoptosis in a manner similar to that of glucocorticoids. |
| S5 |
510-651 |
Sentence |
denotes |
In the absence of TCR-mediated activation, Vpr induces apoptosis whereas in its presence, Vpr interrupts the expected induction of apoptosis. |
| S6 |
652-792 |
Sentence |
denotes |
This regulation of apoptosis is linked to Vpr suppression of NF-kappa B activity via the induction of I kappa B, an inhibitor of NF-kappa B. |
| S7 |
793-909 |
Sentence |
denotes |
Further, Vpr suppresses expression of IL-2, IL-10, IL-12, TNF alpha and IL-4, all of which are NF-kappa B-dependent. |
| S8 |
910-956 |
Sentence |
denotes |
The effects of Vpr could be reversed by RU486. |
| S9 |
957-1115 |
Sentence |
denotes |
Our finding that Vpr can regulate NF-kappa B supports the hypothesis that some aspects of viral pathogenesis are the consequence of cell dysregulation by Vpr. |
