pubmed-sentences-benchmark  

PubMed:9317131 JSONTXT 8 Projects

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Id Subject Object Predicate Lexical cue
S1 0-127 Sentence denotes Cooperation of binding sites for STAT6 and NF kappa B/rel in the IL-4-induced up-regulation of the human IgE germline promoter.
S2 128-234 Sentence denotes Ig heavy chain class switching is directed by cytokines inducing transcription from unrearranged CH genes.
S3 235-336 Sentence denotes Subsequently, such primed cells can undergo switch recombination to express the selected new isotype.
S4 337-556 Sentence denotes In the case of IgE class switching, IL-4 activates the IgE germline promoter by inducing the interaction of the transcription factor STAT6 (IL-4STAT) with a responsive DNA element in the proximal region of the promoter.
S5 557-745 Sentence denotes This study describes the characterization of two additional cis-acting elements that interact with members of the NF kappa B/rel transcription factor family in an IL-4-independent fashion.
S6 746-905 Sentence denotes Electrophoretic mobility shift assays show that the nucleoprotein complex formed on the upstream site (NF kappa B1) contains the classical p50/p65 heterodimer.
S7 906-992 Sentence denotes The complex on the proximal site (NF kappa B2) appears to be composed of p50 and relB.
S8 993-1305 Sentence denotes IgE germline promoter reporter gene constructs carrying point mutations in the NF kappa B2 site were largely unresponsive to IL-4 stimulation in transient transfection experiments, while plasmids with similar mutations in the NF kappa B1 site responded to cytokine stimulation better than the wild-type promoter.
S9 1306-1496 Sentence denotes The NF kappa B2 effect was dependent on the presence of the STAT6 binding site, demonstrating that the NF kappa B2 motif is necessary but not sufficient for mediating cytokine up-regulation.
S10 1497-1695 Sentence denotes In addition, the combination of a NF kappa B/rel binding site and the STAT6 response element conferred IL-4 inducibility to a heterologous minimal promoter, while the individual sites had no effect.
S11 1696-1869 Sentence denotes The available data suggest that the NF kappa B2 nucleoprotein complex may cooperate with DNA-bound STAT6 to achieve IL-4-dependent activation of the human IgE germline gene.