| Id |
Subject |
Object |
Predicate |
Lexical cue |
| S1 |
0-63 |
Sentence |
denotes |
The role of nuclear factor-kappa B in cytokine gene regulation. |
| S2 |
64-141 |
Sentence |
denotes |
Transcription factors are DNA-binding proteins that regulate gene expression. |
| S3 |
142-389 |
Sentence |
denotes |
Nuclear factor-kappa B (NF-kappa B) is a critical transcription factor for maximal expression of many cytokines that are involved in the pathogenesis of inflammatory diseases, such as adult respiratory distress syndrome (ARDS) and sepsis syndrome. |
| S4 |
390-580 |
Sentence |
denotes |
Activation and regulation of NF-kappa B are tightly controlled by a group of inhibitory proteins (I kappa B) that sequester NF-kappa B in the cytoplasm of immune/inflammatory effector cells. |
| S5 |
581-683 |
Sentence |
denotes |
NF-kappa B activation involves signaled phosphorylation, ubiquitination, and proteolysis of I kappa B. |
| S6 |
684-805 |
Sentence |
denotes |
Liberated NF-kappa B migrates to the nucleus, where it binds to specific promoter sites and activates gene transcription. |
| S7 |
806-1002 |
Sentence |
denotes |
The activation of NF-kappa B initiates both extracellular and intracellular regulatory events that result in autoregulation of the inflammatory cascade through modulation of NF-kappa B activation. |
| S8 |
1003-1176 |
Sentence |
denotes |
Recently, activation of NF-kappa B has been linked to ARDS and has been shown to be a critical proximal step in the initiation of neutrophilic inflammation in animal models. |
| S9 |
1177-1317 |
Sentence |
denotes |
Activation of NF-kappa B can be inhibited in vivo by treatment with antioxidants, corticosteroids, and the induction of endotoxin tolerance. |
| S10 |
1318-1486 |
Sentence |
denotes |
Identification of more specific and efficacious inhibitors of NF-kappa B activation might prove beneficial for the treatment of cytokine-mediated inflammatory diseases. |
