| Id |
Subject |
Object |
Predicate |
Lexical cue |
| S1 |
0-150 |
Sentence |
denotes |
Inhibitor (IK) of IFN-gamma induced HLA class II antigens expression also inhibits HLA class II constitutive expression in the human Raji B cell line. |
| S2 |
151-410 |
Sentence |
denotes |
The expression of major histocompatibility complex (MHC) class II antigens is constitutive in professional antigen presenting cells (APCs) but can also be induced by interferon-gamma (IFN-gamma) on the majority of the non professional APCs (e.g. fibroblasts). |
| S3 |
411-556 |
Sentence |
denotes |
We have recently characterised a new factor called IK which is an efficient inhibitor of IFN-gamma induction of MHC class II antigens expression. |
| S4 |
557-779 |
Sentence |
denotes |
Here, we demonstrate a novel role for IK in MHC class II expression since over-expression of this protein by stable transfection into human B cells led to a total disappearance of constitutive MHC class II mRNA expression. |
| S5 |
780-898 |
Sentence |
denotes |
The class II transactivator (CIITA) is necessary for both constitutive and IFN-gamma induced MHC class II expressions. |
| S6 |
899-1013 |
Sentence |
denotes |
Examination of CIITA mRNA in IK stably transfected clones revealed a marked reduction of CIITA mRNA transcription. |
| S7 |
1014-1230 |
Sentence |
denotes |
Taken together these results demonstrate that the IK protein plays a key role in the constitutive expression of MHC class II antigens and that inhibition induced by IK is upstream of CIITA in this regulatory pathway. |
