pubmed-sentences-benchmark  

PubMed:9135552 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
S1 0-100 Sentence denotes The tumour associated cell surface antigen A6H is costimulatory for human CD4+ but not CD8+ T cells.
S2 101-284 Sentence denotes The A6H monoclonal antibody (mAb) recognizes a 120,000-140,000 MW antigen that is expressed at similar densities on 85-90% of human CD4+ and CD8+ T cells and on renal cell carcinomas.
S3 285-373 Sentence denotes The binding of the A6H mAb induced a costimulatory signal in anti-CD3 activated T cells.
S4 374-495 Sentence denotes In the present report, we show that A6H costimulated cell proliferation and cytokine production in purified CD4+ T cells.
S5 496-558 Sentence denotes Unexpectedly, the CD8+ T-cell subpopulation failed to respond.
S6 559-783 Sentence denotes CD4+ T cells costimulated with the A6H mAb upregulated CD80, CD86, CD71, interleukin-2 (IL-2)R alpha, IL-2R beta and IL-2R gamma, while no corresponding up-regulation of these cell surface molecules was seen in CD8+ T cells.
S7 784-1090 Sentence denotes In order to investigate the nature of the A6H mAb costimulus at the transcriptional level we have examined induction of the transcription factors OCT-1, AP-1 and NF-kappa B which are known to be transcriptional regulators of several cytokine and cytokine receptor genes, including the IL-2 and IL-2R genes.
S8 1091-1340 Sentence denotes Co-ligation of the A6H antigen and the CD3 complex induced expression of the transcription factor AP-1 in CD4+ T cells, whereas no increase in NF-kappa B and octamer-binding (Oct) proteins was seen compared to T cells stimulated with anti-CD3 alone.
S9 1341-1417 Sentence denotes Furthermore, no induction of AP-1 was seen in A6H costimulated CD8+ T cells.
S10 1418-1553 Sentence denotes These results suggests that both proximal steps in CD8+ T-cell activation as well as the later phases are unresponsive to A6H ligation.
S11 1554-1714 Sentence denotes Molecular differences of the A6H molecule or distinct regulation of the A6H transduced AP-1 activation pathway may exist in CD4+ and CD8+ T cell subpopulations.