| Id |
Subject |
Object |
Predicate |
Lexical cue |
| S1 |
0-87 |
Sentence |
denotes |
Stimulation of HIV replication in mononuclear phagocytes by leukemia inhibitory factor. |
| S2 |
88-238 |
Sentence |
denotes |
This study examined the effects of leukemia inhibitory factor (LIF) on human immunodeficiency virus (HIV) replication in mononuclear phagocytes (MNP). |
| S3 |
239-357 |
Sentence |
denotes |
LIF induced a dose-dependent increase in p24 antigen production in the chronically infected promonocytic cell line U1. |
| S4 |
358-552 |
Sentence |
denotes |
The magnitude and time kinetics of the LIF effects were similar to interleukin 1 (IL-1), IL-6, and tumor necrosis factor (TNF), other cytokines known to induce HIV replication in this cell line. |
| S5 |
553-789 |
Sentence |
denotes |
To characterize mechanisms responsible for these LIF effects, levels of HIV mRNA, activation of the DNA binding protein nuclear factor (NF)-kB, signal transduction pathways, and potential interactions with other cytokines were analyzed. |
| S6 |
790-860 |
Sentence |
denotes |
LIF increased steady-state levels of HIV mRNA at 2.0, 4.3, and 9.2 kB. |
| S7 |
861-914 |
Sentence |
denotes |
This was detectable by 24 h and persisted until 72 h. |
| S8 |
915-1011 |
Sentence |
denotes |
The DNA binding protein NF-kB is a central mediator in cytokine activation of HIV transcription. |
| S9 |
1012-1103 |
Sentence |
denotes |
NF-kB levels were higher in unstimulated U1 cells as compared to the parent cell line U937. |
| S10 |
1104-1152 |
Sentence |
denotes |
In both cell lines LIF increased NF-kB activity. |
| S11 |
1153-1269 |
Sentence |
denotes |
Induction of NF-kB and HIV replication by cytokines are at least in part dependent on reactive oxygen intermediates. |
| S12 |
1270-1405 |
Sentence |
denotes |
The oxygen radical scavenger N-acetyl-L-cysteine, but not an inhibitor of nitric oxide synthase, inhibited LIF-induced HIV replication. |
| S13 |
1406-1555 |
Sentence |
denotes |
LIF induces the production of other cytokines in monocytes but its effects on HIV replication were not inhibited by antibodies to IL-1, TNF, or IL-6. |
| S14 |
1556-1616 |
Sentence |
denotes |
These results identify LIF as a stimulus of HIV replication. |
| S15 |
1616-1649 |
Sentence |
denotes |
(ABSTRACT TRUNCATED AT 250 WORDS) |
