| Id |
Subject |
Object |
Predicate |
Lexical cue |
| S1 |
0-103 |
Sentence |
denotes |
Activation of pp90rsk and early growth response-1 gene expression by pokeweed mitogen in human B cells. |
| S2 |
104-257 |
Sentence |
denotes |
The present studies have examined the effects of pokeweed mitogen (PWM) on the induction of early growth response-1 gene (EGR-1) in normal human B cells. |
| S3 |
258-354 |
Sentence |
denotes |
PWM regulates EGR-1 gene expression by both transcriptional and post-transcriptional mechanisms. |
| S4 |
355-590 |
Sentence |
denotes |
Transient transfection assays with EGR-1 promoter fragments linked to the chloramphenicol acetyltransferase (CAT) gene demonstrated that PWM induced EGR-1 transcription is conferred by the CArG motif (C C[AT]6GG) in the EGR-1 promoter. |
| S5 |
591-763 |
Sentence |
denotes |
The results further demonstrated the activation of S6 kinase (pp90rsk), evidenced by phosphorylation of S6 and serum response factor (SRF) peptides, in PWM treated B cells. |
| S6 |
764-915 |
Sentence |
denotes |
Taken together, these findings suggest that PWM is able to initiate an intracytoplasmic signalling cascade and EGR-1 induction in normal human B cells. |
